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Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever

Sickle cell disease (SCD) patients are thought to be at higher risk for urinary tract infections (UTIs) compared to the general population secondary to increased sickling, abnormal urinary acidification, and an inability to concentrate the urine. The incidence of UTI in febrile children with SCD in...

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Autores principales: Patel, Nehal, Farooqi, Ahmad, Callaghan, Michael, Sethuraman, Usha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290819/
https://www.ncbi.nlm.nih.gov/pubmed/32438767
http://dx.doi.org/10.3390/jcm9051531
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author Patel, Nehal
Farooqi, Ahmad
Callaghan, Michael
Sethuraman, Usha
author_facet Patel, Nehal
Farooqi, Ahmad
Callaghan, Michael
Sethuraman, Usha
author_sort Patel, Nehal
collection PubMed
description Sickle cell disease (SCD) patients are thought to be at higher risk for urinary tract infections (UTIs) compared to the general population secondary to increased sickling, abnormal urinary acidification, and an inability to concentrate the urine. The incidence of UTI in febrile children with SCD in the United States is unknown. Our objectives were to determine the rate of UTI among febrile SCD children and describe the risk factors for UTI in this population. We conducted a retrospective chart review of all febrile SCD patients <4 years of age who presented to a pediatric emergency department from 2012–2017 and who had a sterile sample of urine for analysis. A total of 167 febrile patients with SCD with 464 visits were identified. The majority were African American (95.2%), female (58.7%), and had hemoglobin SS (HbSS) (65.3%). The rate of UTI was 4.1%. All patients with a UTI were African American females with a median age of 19 months (IQR 12–30). On regression analysis, no risk factors were associated with a UTI. We found the rate of UTI in febrile young children with SCD was comparable to non-SCD children. Larger studies are required to identify the presence of risk factors for UTI in this population.
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spelling pubmed-72908192020-06-17 Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever Patel, Nehal Farooqi, Ahmad Callaghan, Michael Sethuraman, Usha J Clin Med Article Sickle cell disease (SCD) patients are thought to be at higher risk for urinary tract infections (UTIs) compared to the general population secondary to increased sickling, abnormal urinary acidification, and an inability to concentrate the urine. The incidence of UTI in febrile children with SCD in the United States is unknown. Our objectives were to determine the rate of UTI among febrile SCD children and describe the risk factors for UTI in this population. We conducted a retrospective chart review of all febrile SCD patients <4 years of age who presented to a pediatric emergency department from 2012–2017 and who had a sterile sample of urine for analysis. A total of 167 febrile patients with SCD with 464 visits were identified. The majority were African American (95.2%), female (58.7%), and had hemoglobin SS (HbSS) (65.3%). The rate of UTI was 4.1%. All patients with a UTI were African American females with a median age of 19 months (IQR 12–30). On regression analysis, no risk factors were associated with a UTI. We found the rate of UTI in febrile young children with SCD was comparable to non-SCD children. Larger studies are required to identify the presence of risk factors for UTI in this population. MDPI 2020-05-19 /pmc/articles/PMC7290819/ /pubmed/32438767 http://dx.doi.org/10.3390/jcm9051531 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Patel, Nehal
Farooqi, Ahmad
Callaghan, Michael
Sethuraman, Usha
Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
title Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
title_full Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
title_fullStr Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
title_full_unstemmed Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
title_short Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
title_sort urinary tract infection in febrile children with sickle cell disease who present to the emergency room with fever
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290819/
https://www.ncbi.nlm.nih.gov/pubmed/32438767
http://dx.doi.org/10.3390/jcm9051531
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