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Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis

Acute pancreatitis (AP) manifests itself either as a mild, self-limiting inflammation or a severe, systemic inflammatory process that is associated with various complications and a high mortality rate. It is unknown whether these two forms of the disease can differ in the profile of circulating glyc...

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Autores principales: Koźma, Ewa M., Kuźnik-Trocha, Kornelia, Winsz-Szczotka, Katarzyna, Wisowski, Grzegorz, Olczyk, Paweł, Komosińska-Vassev, Katarzyna, Kasperczyk, Mariusz, Olczyk, Krystyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290898/
https://www.ncbi.nlm.nih.gov/pubmed/32370095
http://dx.doi.org/10.3390/jcm9051308
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author Koźma, Ewa M.
Kuźnik-Trocha, Kornelia
Winsz-Szczotka, Katarzyna
Wisowski, Grzegorz
Olczyk, Paweł
Komosińska-Vassev, Katarzyna
Kasperczyk, Mariusz
Olczyk, Krystyna
author_facet Koźma, Ewa M.
Kuźnik-Trocha, Kornelia
Winsz-Szczotka, Katarzyna
Wisowski, Grzegorz
Olczyk, Paweł
Komosińska-Vassev, Katarzyna
Kasperczyk, Mariusz
Olczyk, Krystyna
author_sort Koźma, Ewa M.
collection PubMed
description Acute pancreatitis (AP) manifests itself either as a mild, self-limiting inflammation or a severe, systemic inflammatory process that is associated with various complications and a high mortality rate. It is unknown whether these two forms of the disease can differ in the profile of circulating glycosaminoglycans, which are molecules with huge biological reactivity due to a high density of negative electric charge. Plasma glycosaminoglycans were characterized/quantified in 23 healthy controls, 32 patients with mild AP, and 15 individuals with severe disease using electrophoresis with enzymatic identification (chondroitin sulfate and heparan sulfate) or an ELISA-based test (hyaluronan). Moreover, the correlations between the glycosaminoglycan levels and clinical parameters were evaluated. Both forms of AP showed similar remodeling of the plasma profile of the sulfated glycosaminoglycans. In contrast, only in the patients with mild AP was the level of circulating hyaluronan significantly decreased as compared to the healthy controls. Both forms of AP are associated with systemic changes in the metabolism of glycosaminoglycans. However, the alterations in hyaluronan metabolism may contribute to the disease evolution. The circulating hyaluronan may have some clinical value to predict the severity of AP and to evaluate the clinical status of patients with severe AP.
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spelling pubmed-72908982020-06-17 Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis Koźma, Ewa M. Kuźnik-Trocha, Kornelia Winsz-Szczotka, Katarzyna Wisowski, Grzegorz Olczyk, Paweł Komosińska-Vassev, Katarzyna Kasperczyk, Mariusz Olczyk, Krystyna J Clin Med Article Acute pancreatitis (AP) manifests itself either as a mild, self-limiting inflammation or a severe, systemic inflammatory process that is associated with various complications and a high mortality rate. It is unknown whether these two forms of the disease can differ in the profile of circulating glycosaminoglycans, which are molecules with huge biological reactivity due to a high density of negative electric charge. Plasma glycosaminoglycans were characterized/quantified in 23 healthy controls, 32 patients with mild AP, and 15 individuals with severe disease using electrophoresis with enzymatic identification (chondroitin sulfate and heparan sulfate) or an ELISA-based test (hyaluronan). Moreover, the correlations between the glycosaminoglycan levels and clinical parameters were evaluated. Both forms of AP showed similar remodeling of the plasma profile of the sulfated glycosaminoglycans. In contrast, only in the patients with mild AP was the level of circulating hyaluronan significantly decreased as compared to the healthy controls. Both forms of AP are associated with systemic changes in the metabolism of glycosaminoglycans. However, the alterations in hyaluronan metabolism may contribute to the disease evolution. The circulating hyaluronan may have some clinical value to predict the severity of AP and to evaluate the clinical status of patients with severe AP. MDPI 2020-05-01 /pmc/articles/PMC7290898/ /pubmed/32370095 http://dx.doi.org/10.3390/jcm9051308 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koźma, Ewa M.
Kuźnik-Trocha, Kornelia
Winsz-Szczotka, Katarzyna
Wisowski, Grzegorz
Olczyk, Paweł
Komosińska-Vassev, Katarzyna
Kasperczyk, Mariusz
Olczyk, Krystyna
Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
title Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
title_full Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
title_fullStr Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
title_full_unstemmed Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
title_short Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
title_sort significant remodeling affects the circulating glycosaminoglycan profile in adult patients with both severe and mild forms of acute pancreatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290898/
https://www.ncbi.nlm.nih.gov/pubmed/32370095
http://dx.doi.org/10.3390/jcm9051308
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