Cargando…
Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 i...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290913/ https://www.ncbi.nlm.nih.gov/pubmed/32380691 http://dx.doi.org/10.3390/cells9051135 |
_version_ | 1783545787339243520 |
---|---|
author | Donizy, Piotr Wu, Cheng-Lin Mull, Jason Fujimoto, Masakazu Chłopik, Agata Peng, Yan Shalin, Sara C. Selim, M. Angelica Puig, Susana Fernandez-Figueras, Maria-Teresa Shea, Christopher R. Biernat, Wojciech Ryś, Janusz Marszalek, Andrzej Hoang, Mai P. |
author_facet | Donizy, Piotr Wu, Cheng-Lin Mull, Jason Fujimoto, Masakazu Chłopik, Agata Peng, Yan Shalin, Sara C. Selim, M. Angelica Puig, Susana Fernandez-Figueras, Maria-Teresa Shea, Christopher R. Biernat, Wojciech Ryś, Janusz Marszalek, Andrzej Hoang, Mai P. |
author_sort | Donizy, Piotr |
collection | PubMed |
description | Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 immunostains were performed on 192 mucosal melanomas including 86 vulvar, 89 sinonasal, and 17 anorectal melanomas. Results: By Kaplan–Meier analyses, high PARP1 expression correlated with worse overall and melanoma-specific survival (log-rank p values = 0.026 and 0.047, respectively). Tumors with combined PARP1 and IDO1 high expression correlated with worse overall and melanoma-specific survival (p = 0.015, 0.0034 respectively). By multivariate analyses, high PARP1 expression remained a predictor of worse survival independent of stage. By Fisher’s exact test, high PARP1 expression correlated with highly mitogenic tumors (p = 0.02). High tumoral PD-L1 and IDO1 expression were associated with ulcerated primary tumors (p = 0.019, 0.0019, respectively). By linear regression analyses, correlations between PARP1 expression versus IDO1 expression (p = 0.0001) and mitotic index (p = 0.0052) were observed. Conclusion: Increased expression of PARP1 is an independent negative prognostic marker in mucosal melanomas. The association between PARP1 and IDO1 and their combined adverse prognostic role raise the potential of combined therapy in mucosal melanoma. |
format | Online Article Text |
id | pubmed-7290913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72909132020-06-17 Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas Donizy, Piotr Wu, Cheng-Lin Mull, Jason Fujimoto, Masakazu Chłopik, Agata Peng, Yan Shalin, Sara C. Selim, M. Angelica Puig, Susana Fernandez-Figueras, Maria-Teresa Shea, Christopher R. Biernat, Wojciech Ryś, Janusz Marszalek, Andrzej Hoang, Mai P. Cells Article Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 immunostains were performed on 192 mucosal melanomas including 86 vulvar, 89 sinonasal, and 17 anorectal melanomas. Results: By Kaplan–Meier analyses, high PARP1 expression correlated with worse overall and melanoma-specific survival (log-rank p values = 0.026 and 0.047, respectively). Tumors with combined PARP1 and IDO1 high expression correlated with worse overall and melanoma-specific survival (p = 0.015, 0.0034 respectively). By multivariate analyses, high PARP1 expression remained a predictor of worse survival independent of stage. By Fisher’s exact test, high PARP1 expression correlated with highly mitogenic tumors (p = 0.02). High tumoral PD-L1 and IDO1 expression were associated with ulcerated primary tumors (p = 0.019, 0.0019, respectively). By linear regression analyses, correlations between PARP1 expression versus IDO1 expression (p = 0.0001) and mitotic index (p = 0.0052) were observed. Conclusion: Increased expression of PARP1 is an independent negative prognostic marker in mucosal melanomas. The association between PARP1 and IDO1 and their combined adverse prognostic role raise the potential of combined therapy in mucosal melanoma. MDPI 2020-05-05 /pmc/articles/PMC7290913/ /pubmed/32380691 http://dx.doi.org/10.3390/cells9051135 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Donizy, Piotr Wu, Cheng-Lin Mull, Jason Fujimoto, Masakazu Chłopik, Agata Peng, Yan Shalin, Sara C. Selim, M. Angelica Puig, Susana Fernandez-Figueras, Maria-Teresa Shea, Christopher R. Biernat, Wojciech Ryś, Janusz Marszalek, Andrzej Hoang, Mai P. Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas |
title | Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas |
title_full | Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas |
title_fullStr | Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas |
title_full_unstemmed | Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas |
title_short | Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas |
title_sort | up-regulation of parp1 expression significantly correlated with poor survival in mucosal melanomas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290913/ https://www.ncbi.nlm.nih.gov/pubmed/32380691 http://dx.doi.org/10.3390/cells9051135 |
work_keys_str_mv | AT donizypiotr upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT wuchenglin upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT mulljason upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT fujimotomasakazu upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT chłopikagata upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT pengyan upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT shalinsarac upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT selimmangelica upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT puigsusana upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT fernandezfiguerasmariateresa upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT sheachristopherr upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT biernatwojciech upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT rysjanusz upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT marszalekandrzej upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas AT hoangmaip upregulationofparp1expressionsignificantlycorrelatedwithpoorsurvivalinmucosalmelanomas |