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Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas

Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 i...

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Autores principales: Donizy, Piotr, Wu, Cheng-Lin, Mull, Jason, Fujimoto, Masakazu, Chłopik, Agata, Peng, Yan, Shalin, Sara C., Selim, M. Angelica, Puig, Susana, Fernandez-Figueras, Maria-Teresa, Shea, Christopher R., Biernat, Wojciech, Ryś, Janusz, Marszalek, Andrzej, Hoang, Mai P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290913/
https://www.ncbi.nlm.nih.gov/pubmed/32380691
http://dx.doi.org/10.3390/cells9051135
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author Donizy, Piotr
Wu, Cheng-Lin
Mull, Jason
Fujimoto, Masakazu
Chłopik, Agata
Peng, Yan
Shalin, Sara C.
Selim, M. Angelica
Puig, Susana
Fernandez-Figueras, Maria-Teresa
Shea, Christopher R.
Biernat, Wojciech
Ryś, Janusz
Marszalek, Andrzej
Hoang, Mai P.
author_facet Donizy, Piotr
Wu, Cheng-Lin
Mull, Jason
Fujimoto, Masakazu
Chłopik, Agata
Peng, Yan
Shalin, Sara C.
Selim, M. Angelica
Puig, Susana
Fernandez-Figueras, Maria-Teresa
Shea, Christopher R.
Biernat, Wojciech
Ryś, Janusz
Marszalek, Andrzej
Hoang, Mai P.
author_sort Donizy, Piotr
collection PubMed
description Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 immunostains were performed on 192 mucosal melanomas including 86 vulvar, 89 sinonasal, and 17 anorectal melanomas. Results: By Kaplan–Meier analyses, high PARP1 expression correlated with worse overall and melanoma-specific survival (log-rank p values = 0.026 and 0.047, respectively). Tumors with combined PARP1 and IDO1 high expression correlated with worse overall and melanoma-specific survival (p = 0.015, 0.0034 respectively). By multivariate analyses, high PARP1 expression remained a predictor of worse survival independent of stage. By Fisher’s exact test, high PARP1 expression correlated with highly mitogenic tumors (p = 0.02). High tumoral PD-L1 and IDO1 expression were associated with ulcerated primary tumors (p = 0.019, 0.0019, respectively). By linear regression analyses, correlations between PARP1 expression versus IDO1 expression (p = 0.0001) and mitotic index (p = 0.0052) were observed. Conclusion: Increased expression of PARP1 is an independent negative prognostic marker in mucosal melanomas. The association between PARP1 and IDO1 and their combined adverse prognostic role raise the potential of combined therapy in mucosal melanoma.
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spelling pubmed-72909132020-06-17 Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas Donizy, Piotr Wu, Cheng-Lin Mull, Jason Fujimoto, Masakazu Chłopik, Agata Peng, Yan Shalin, Sara C. Selim, M. Angelica Puig, Susana Fernandez-Figueras, Maria-Teresa Shea, Christopher R. Biernat, Wojciech Ryś, Janusz Marszalek, Andrzej Hoang, Mai P. Cells Article Introduction: Mucosal melanoma is rare and associated with poorer prognosis in comparison to conventional melanoma subtypes. Little is known about the prognostic significance as well as possible associations between PARP1 and immunologic response in mucosal melanoma. Methods: PARP1, PD-L1 and IDO1 immunostains were performed on 192 mucosal melanomas including 86 vulvar, 89 sinonasal, and 17 anorectal melanomas. Results: By Kaplan–Meier analyses, high PARP1 expression correlated with worse overall and melanoma-specific survival (log-rank p values = 0.026 and 0.047, respectively). Tumors with combined PARP1 and IDO1 high expression correlated with worse overall and melanoma-specific survival (p = 0.015, 0.0034 respectively). By multivariate analyses, high PARP1 expression remained a predictor of worse survival independent of stage. By Fisher’s exact test, high PARP1 expression correlated with highly mitogenic tumors (p = 0.02). High tumoral PD-L1 and IDO1 expression were associated with ulcerated primary tumors (p = 0.019, 0.0019, respectively). By linear regression analyses, correlations between PARP1 expression versus IDO1 expression (p = 0.0001) and mitotic index (p = 0.0052) were observed. Conclusion: Increased expression of PARP1 is an independent negative prognostic marker in mucosal melanomas. The association between PARP1 and IDO1 and their combined adverse prognostic role raise the potential of combined therapy in mucosal melanoma. MDPI 2020-05-05 /pmc/articles/PMC7290913/ /pubmed/32380691 http://dx.doi.org/10.3390/cells9051135 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Donizy, Piotr
Wu, Cheng-Lin
Mull, Jason
Fujimoto, Masakazu
Chłopik, Agata
Peng, Yan
Shalin, Sara C.
Selim, M. Angelica
Puig, Susana
Fernandez-Figueras, Maria-Teresa
Shea, Christopher R.
Biernat, Wojciech
Ryś, Janusz
Marszalek, Andrzej
Hoang, Mai P.
Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
title Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
title_full Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
title_fullStr Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
title_full_unstemmed Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
title_short Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas
title_sort up-regulation of parp1 expression significantly correlated with poor survival in mucosal melanomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290913/
https://www.ncbi.nlm.nih.gov/pubmed/32380691
http://dx.doi.org/10.3390/cells9051135
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