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Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data

SARS-CoV-2 is responsible for a highly contagious infection, known as COVID-19. SARS-CoV-2 was discovered in late December 2019 and, since then, has become a global pandemic. Timely and accurate COVID-19 laboratory testing is an essential step in the management of the COVID-19 outbreak. To date, ass...

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Autores principales: Riccò, Matteo, Ferraro, Pietro, Gualerzi, Giovanni, Ranzieri, Silvia, Henry, Brandon Michael, Said, Younes Ben, Pyatigorskaya, Natalia Valeryevna, Nevolina, Elena, Wu, Jianhong, Bragazzi, Nicola Luigi, Signorelli, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290955/
https://www.ncbi.nlm.nih.gov/pubmed/32443459
http://dx.doi.org/10.3390/jcm9051515
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author Riccò, Matteo
Ferraro, Pietro
Gualerzi, Giovanni
Ranzieri, Silvia
Henry, Brandon Michael
Said, Younes Ben
Pyatigorskaya, Natalia Valeryevna
Nevolina, Elena
Wu, Jianhong
Bragazzi, Nicola Luigi
Signorelli, Carlo
author_facet Riccò, Matteo
Ferraro, Pietro
Gualerzi, Giovanni
Ranzieri, Silvia
Henry, Brandon Michael
Said, Younes Ben
Pyatigorskaya, Natalia Valeryevna
Nevolina, Elena
Wu, Jianhong
Bragazzi, Nicola Luigi
Signorelli, Carlo
author_sort Riccò, Matteo
collection PubMed
description SARS-CoV-2 is responsible for a highly contagious infection, known as COVID-19. SARS-CoV-2 was discovered in late December 2019 and, since then, has become a global pandemic. Timely and accurate COVID-19 laboratory testing is an essential step in the management of the COVID-19 outbreak. To date, assays based on the reverse-transcription polymerase chain reaction (RT-PCR) in respiratory samples are the gold standard for COVID-19 diagnosis. Unfortunately, RT-PCR has several practical limitations. Consequently, alternative diagnostic methods are urgently required, both for alleviating the pressure on laboratories and healthcare facilities and for expanding testing capacity to enable large-scale screening and ensure a timely therapeutic intervention. To date, few studies have been conducted concerning the potential utilization of rapid testing for COVID-19, with some conflicting results. Therefore, the present systematic review and meta-analysis was undertaken to explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak. Based on ten studies, we computed a pooled sensitivity of 64.8% (95%CI 54.5–74.0), and specificity of 98.0% (95%CI 95.8–99.0), with high heterogeneity and risk of reporting bias. We can conclude that: (1) rapid diagnostic tests for COVID-19 are necessary, but should be adequately sensitive and specific; (2) few studies have been carried out to date; (3) the studies included are characterized by low numbers and low sample power, and (4) in light of these results, the use of available tests is currently questionable for clinical purposes and cannot substitute other more reliable molecular tests, such as assays based on RT-PCR.
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spelling pubmed-72909552020-06-17 Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data Riccò, Matteo Ferraro, Pietro Gualerzi, Giovanni Ranzieri, Silvia Henry, Brandon Michael Said, Younes Ben Pyatigorskaya, Natalia Valeryevna Nevolina, Elena Wu, Jianhong Bragazzi, Nicola Luigi Signorelli, Carlo J Clin Med Review SARS-CoV-2 is responsible for a highly contagious infection, known as COVID-19. SARS-CoV-2 was discovered in late December 2019 and, since then, has become a global pandemic. Timely and accurate COVID-19 laboratory testing is an essential step in the management of the COVID-19 outbreak. To date, assays based on the reverse-transcription polymerase chain reaction (RT-PCR) in respiratory samples are the gold standard for COVID-19 diagnosis. Unfortunately, RT-PCR has several practical limitations. Consequently, alternative diagnostic methods are urgently required, both for alleviating the pressure on laboratories and healthcare facilities and for expanding testing capacity to enable large-scale screening and ensure a timely therapeutic intervention. To date, few studies have been conducted concerning the potential utilization of rapid testing for COVID-19, with some conflicting results. Therefore, the present systematic review and meta-analysis was undertaken to explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak. Based on ten studies, we computed a pooled sensitivity of 64.8% (95%CI 54.5–74.0), and specificity of 98.0% (95%CI 95.8–99.0), with high heterogeneity and risk of reporting bias. We can conclude that: (1) rapid diagnostic tests for COVID-19 are necessary, but should be adequately sensitive and specific; (2) few studies have been carried out to date; (3) the studies included are characterized by low numbers and low sample power, and (4) in light of these results, the use of available tests is currently questionable for clinical purposes and cannot substitute other more reliable molecular tests, such as assays based on RT-PCR. MDPI 2020-05-18 /pmc/articles/PMC7290955/ /pubmed/32443459 http://dx.doi.org/10.3390/jcm9051515 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Riccò, Matteo
Ferraro, Pietro
Gualerzi, Giovanni
Ranzieri, Silvia
Henry, Brandon Michael
Said, Younes Ben
Pyatigorskaya, Natalia Valeryevna
Nevolina, Elena
Wu, Jianhong
Bragazzi, Nicola Luigi
Signorelli, Carlo
Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data
title Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data
title_full Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data
title_fullStr Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data
title_full_unstemmed Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data
title_short Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data
title_sort point-of-care diagnostic tests for detecting sars-cov-2 antibodies: a systematic review and meta-analysis of real-world data
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290955/
https://www.ncbi.nlm.nih.gov/pubmed/32443459
http://dx.doi.org/10.3390/jcm9051515
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