DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines

Trastuzumab emtansine (T-DM1) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugated to the microtubule-targeting agent emtansine (DM1). T-DM1 is an effective agent in the treatment of patients with HER2-positive breast cancer whose disease has progressed on the first-li...

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Detalles Bibliográficos
Autores principales: D’Amico, Silvia, Krasnowska, Ewa Krystyna, Manni, Isabella, Toietta, Gabriele, Baldari, Silvia, Piaggio, Giulia, Ranalli, Marco, Gambacurta, Alessandra, Vernieri, Claudio, Di Giacinto, Flavio, Bernassola, Francesca, de Braud, Filippo, Lucibello, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290969/
https://www.ncbi.nlm.nih.gov/pubmed/32438775
http://dx.doi.org/10.3390/cells9051260

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