Cargando…

Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease

Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their vital functions, mitochondrial quality control (MQC) systems are in place to support organelle plasticity as well as physical and functional connections with other cellular compartments. In particular, m...

Descripción completa

Detalles Bibliográficos
Autores principales: Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Junior, Hélio José, Bossola, Maurizio, Landi, Francesco, Bernabei, Roberto, Bucci, Cecilia, Marzetti, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290979/
https://www.ncbi.nlm.nih.gov/pubmed/32408624
http://dx.doi.org/10.3390/jcm9051440
_version_ 1783545802787913728
author Picca, Anna
Guerra, Flora
Calvani, Riccardo
Coelho-Junior, Hélio José
Bossola, Maurizio
Landi, Francesco
Bernabei, Roberto
Bucci, Cecilia
Marzetti, Emanuele
author_facet Picca, Anna
Guerra, Flora
Calvani, Riccardo
Coelho-Junior, Hélio José
Bossola, Maurizio
Landi, Francesco
Bernabei, Roberto
Bucci, Cecilia
Marzetti, Emanuele
author_sort Picca, Anna
collection PubMed
description Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their vital functions, mitochondrial quality control (MQC) systems are in place to support organelle plasticity as well as physical and functional connections with other cellular compartments. In particular, mitochondrial interactions with the endosomal compartment support the shuttle of ions and metabolites across organelles, while those with lysosomes ensure the recycling of obsolete materials. The extrusion of mitochondrial components via the generation and release of mitochondrial-derived vesicles (MDVs) has recently been described. MDV trafficking is now included among MQC pathways, possibly operating via mitochondrial–lysosomal contacts. Since mitochondrial dysfunction is acknowledged as a hallmark of aging and a major pathogenic factor of multiple age-associated conditions, the analysis of MDVs and, more generally, of extracellular vesicles (EVs) is recognized as a valuable research tool. The dissection of EV trafficking may help unravel new pathophysiological pathways of aging and diseases as well as novel biomarkers to be used in research and clinical settings. Here, we discuss (1) MQC pathways with a focus on mitophagy and MDV generation; (2) changes of MQC pathways during aging and their contribution to inflamm-aging and progeroid conditions; and (3) the relevance of MQC failure to several disorders, including neurodegenerative conditions (i.e., Parkinson’s disease, Alzheimer’s disease) and cardiovascular disease.
format Online
Article
Text
id pubmed-7290979
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72909792020-06-17 Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease Picca, Anna Guerra, Flora Calvani, Riccardo Coelho-Junior, Hélio José Bossola, Maurizio Landi, Francesco Bernabei, Roberto Bucci, Cecilia Marzetti, Emanuele J Clin Med Review Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their vital functions, mitochondrial quality control (MQC) systems are in place to support organelle plasticity as well as physical and functional connections with other cellular compartments. In particular, mitochondrial interactions with the endosomal compartment support the shuttle of ions and metabolites across organelles, while those with lysosomes ensure the recycling of obsolete materials. The extrusion of mitochondrial components via the generation and release of mitochondrial-derived vesicles (MDVs) has recently been described. MDV trafficking is now included among MQC pathways, possibly operating via mitochondrial–lysosomal contacts. Since mitochondrial dysfunction is acknowledged as a hallmark of aging and a major pathogenic factor of multiple age-associated conditions, the analysis of MDVs and, more generally, of extracellular vesicles (EVs) is recognized as a valuable research tool. The dissection of EV trafficking may help unravel new pathophysiological pathways of aging and diseases as well as novel biomarkers to be used in research and clinical settings. Here, we discuss (1) MQC pathways with a focus on mitophagy and MDV generation; (2) changes of MQC pathways during aging and their contribution to inflamm-aging and progeroid conditions; and (3) the relevance of MQC failure to several disorders, including neurodegenerative conditions (i.e., Parkinson’s disease, Alzheimer’s disease) and cardiovascular disease. MDPI 2020-05-12 /pmc/articles/PMC7290979/ /pubmed/32408624 http://dx.doi.org/10.3390/jcm9051440 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Picca, Anna
Guerra, Flora
Calvani, Riccardo
Coelho-Junior, Hélio José
Bossola, Maurizio
Landi, Francesco
Bernabei, Roberto
Bucci, Cecilia
Marzetti, Emanuele
Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
title Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
title_full Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
title_fullStr Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
title_full_unstemmed Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
title_short Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
title_sort generation and release of mitochondrial-derived vesicles in health, aging and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290979/
https://www.ncbi.nlm.nih.gov/pubmed/32408624
http://dx.doi.org/10.3390/jcm9051440
work_keys_str_mv AT piccaanna generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT guerraflora generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT calvaniriccardo generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT coelhojuniorheliojose generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT bossolamaurizio generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT landifrancesco generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT bernabeiroberto generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT buccicecilia generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease
AT marzettiemanuele generationandreleaseofmitochondrialderivedvesiclesinhealthaginganddisease