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MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes— Epstein-Barr virus (EBV)-positive, microsatellite...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291039/ https://www.ncbi.nlm.nih.gov/pubmed/32403403 http://dx.doi.org/10.3390/jcm9051427 |
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author | Rodriquenz, Maria Grazia Roviello, Giandomenico D’Angelo, Alberto Lavacchi, Daniele Roviello, Franco Polom, Karol |
author_facet | Rodriquenz, Maria Grazia Roviello, Giandomenico D’Angelo, Alberto Lavacchi, Daniele Roviello, Franco Polom, Karol |
author_sort | Rodriquenz, Maria Grazia |
collection | PubMed |
description | Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes— Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer’s subgroups and their relationship with novel immunotherapy. |
format | Online Article Text |
id | pubmed-7291039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72910392020-06-17 MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy Rodriquenz, Maria Grazia Roviello, Giandomenico D’Angelo, Alberto Lavacchi, Daniele Roviello, Franco Polom, Karol J Clin Med Review Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes— Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer’s subgroups and their relationship with novel immunotherapy. MDPI 2020-05-11 /pmc/articles/PMC7291039/ /pubmed/32403403 http://dx.doi.org/10.3390/jcm9051427 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodriquenz, Maria Grazia Roviello, Giandomenico D’Angelo, Alberto Lavacchi, Daniele Roviello, Franco Polom, Karol MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy |
title | MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy |
title_full | MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy |
title_fullStr | MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy |
title_full_unstemmed | MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy |
title_short | MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy |
title_sort | msi and ebv positive gastric cancer’s subgroups and their link with novel immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291039/ https://www.ncbi.nlm.nih.gov/pubmed/32403403 http://dx.doi.org/10.3390/jcm9051427 |
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