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MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy

Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes— Epstein-Barr virus (EBV)-positive, microsatellite...

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Autores principales: Rodriquenz, Maria Grazia, Roviello, Giandomenico, D’Angelo, Alberto, Lavacchi, Daniele, Roviello, Franco, Polom, Karol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291039/
https://www.ncbi.nlm.nih.gov/pubmed/32403403
http://dx.doi.org/10.3390/jcm9051427
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author Rodriquenz, Maria Grazia
Roviello, Giandomenico
D’Angelo, Alberto
Lavacchi, Daniele
Roviello, Franco
Polom, Karol
author_facet Rodriquenz, Maria Grazia
Roviello, Giandomenico
D’Angelo, Alberto
Lavacchi, Daniele
Roviello, Franco
Polom, Karol
author_sort Rodriquenz, Maria Grazia
collection PubMed
description Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes— Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer’s subgroups and their relationship with novel immunotherapy.
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spelling pubmed-72910392020-06-17 MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy Rodriquenz, Maria Grazia Roviello, Giandomenico D’Angelo, Alberto Lavacchi, Daniele Roviello, Franco Polom, Karol J Clin Med Review Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes— Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer’s subgroups and their relationship with novel immunotherapy. MDPI 2020-05-11 /pmc/articles/PMC7291039/ /pubmed/32403403 http://dx.doi.org/10.3390/jcm9051427 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rodriquenz, Maria Grazia
Roviello, Giandomenico
D’Angelo, Alberto
Lavacchi, Daniele
Roviello, Franco
Polom, Karol
MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
title MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
title_full MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
title_fullStr MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
title_full_unstemmed MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
title_short MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
title_sort msi and ebv positive gastric cancer’s subgroups and their link with novel immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291039/
https://www.ncbi.nlm.nih.gov/pubmed/32403403
http://dx.doi.org/10.3390/jcm9051427
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