Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold

Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects. To ensure efficacy and safe CAR-T cell therapy, it is important to understand CAR’s structure–activity relationship. To clarify the rol...

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Detalles Bibliográficos
Autores principales: Fujiwara, Kento, Tsunei, Ayaka, Kusabuka, Hotaka, Ogaki, Erika, Tachibana, Masashi, Okada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291079/
https://www.ncbi.nlm.nih.gov/pubmed/32397414
http://dx.doi.org/10.3390/cells9051182

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