Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells

We recently identified elevated annexin A6 (AnxA6) protein levels in Niemann–Pick-type C1 (NPC1) mutant cells. In these cells, AnxA6 depletion rescued the cholesterol accumulation associated with NPC1 deficiency. Here, we demonstrate that elevated AnxA6 protein levels in NPC1 mutants or upon pharmac...

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Detalles Bibliográficos
Autores principales: Meneses-Salas, Elsa, García-Melero, Ana, Blanco-Muñoz, Patricia, Jose, Jaimy, Brenner, Marie-Sophie, Lu, Albert, Tebar, Francesc, Grewal, Thomas, Rentero, Carles, Enrich, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291204/
https://www.ncbi.nlm.nih.gov/pubmed/32392809
http://dx.doi.org/10.3390/cells9051152

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