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Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute is...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291207/ https://www.ncbi.nlm.nih.gov/pubmed/32422921 http://dx.doi.org/10.3390/jcm9051471 |
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author | Yoo, Joonsang Hong, Jeong-Ho Lee, Seong-Joon Kim, Yong-Won Hong, Ji Man Kim, Chang-Hyun Choi, Jin Wook Kang, Dong-Hun Kim, Yong-Sun Hwang, Yang-Ha Lee, Jin Soo Sohn, Sung-Il |
author_facet | Yoo, Joonsang Hong, Jeong-Ho Lee, Seong-Joon Kim, Yong-Won Hong, Ji Man Kim, Chang-Hyun Choi, Jin Wook Kang, Dong-Hun Kim, Yong-Sun Hwang, Yang-Ha Lee, Jin Soo Sohn, Sung-Il |
author_sort | Yoo, Joonsang |
collection | PubMed |
description | Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. We compared the characteristics of patients with and without AKI and independent factors associated with AKI after EVT. We also investigated the effects of AKI on functional outcomes and mortality at 3 months. Of the 601 patients analyzed, 59 patients (9.8%) developed AKI and five patients (0.8%) started renal replacement therapy after EVT. In the multivariate analysis, diabetes mellitus (odds ratio (OR), 2.341; 95% CI, 1.283–4.269; p = 0.005), the contrast agent dose (OR, 1.107 per 10 mL; 95% CI, 1.032–1.187; p = 0.004), and unsuccessful reperfusion (OR, 1.909; 95% CI, 1.019–3.520; p = 0.040) were independently associated with AKI. The presence of AKI was associated with a poor functional outcome (OR, 5.145; 95% CI, 2.177–13.850; p < 0.001) and mortality (OR, 8.164; 95% CI, 4.046–16.709; p < 0.001) at 3 months. AKI may also affect the outcomes of ischemic stroke patients undergoing EVT. When implementing EVT, practitioners should be aware of these risk factors. |
format | Online Article Text |
id | pubmed-7291207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72912072020-06-17 Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke Yoo, Joonsang Hong, Jeong-Ho Lee, Seong-Joon Kim, Yong-Won Hong, Ji Man Kim, Chang-Hyun Choi, Jin Wook Kang, Dong-Hun Kim, Yong-Sun Hwang, Yang-Ha Lee, Jin Soo Sohn, Sung-Il J Clin Med Article Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. We compared the characteristics of patients with and without AKI and independent factors associated with AKI after EVT. We also investigated the effects of AKI on functional outcomes and mortality at 3 months. Of the 601 patients analyzed, 59 patients (9.8%) developed AKI and five patients (0.8%) started renal replacement therapy after EVT. In the multivariate analysis, diabetes mellitus (odds ratio (OR), 2.341; 95% CI, 1.283–4.269; p = 0.005), the contrast agent dose (OR, 1.107 per 10 mL; 95% CI, 1.032–1.187; p = 0.004), and unsuccessful reperfusion (OR, 1.909; 95% CI, 1.019–3.520; p = 0.040) were independently associated with AKI. The presence of AKI was associated with a poor functional outcome (OR, 5.145; 95% CI, 2.177–13.850; p < 0.001) and mortality (OR, 8.164; 95% CI, 4.046–16.709; p < 0.001) at 3 months. AKI may also affect the outcomes of ischemic stroke patients undergoing EVT. When implementing EVT, practitioners should be aware of these risk factors. MDPI 2020-05-14 /pmc/articles/PMC7291207/ /pubmed/32422921 http://dx.doi.org/10.3390/jcm9051471 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yoo, Joonsang Hong, Jeong-Ho Lee, Seong-Joon Kim, Yong-Won Hong, Ji Man Kim, Chang-Hyun Choi, Jin Wook Kang, Dong-Hun Kim, Yong-Sun Hwang, Yang-Ha Lee, Jin Soo Sohn, Sung-Il Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke |
title | Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke |
title_full | Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke |
title_fullStr | Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke |
title_full_unstemmed | Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke |
title_short | Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke |
title_sort | acute kidney injury after endovascular treatment in patients with acute ischemic stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291207/ https://www.ncbi.nlm.nih.gov/pubmed/32422921 http://dx.doi.org/10.3390/jcm9051471 |
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