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Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke

Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute is...

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Autores principales: Yoo, Joonsang, Hong, Jeong-Ho, Lee, Seong-Joon, Kim, Yong-Won, Hong, Ji Man, Kim, Chang-Hyun, Choi, Jin Wook, Kang, Dong-Hun, Kim, Yong-Sun, Hwang, Yang-Ha, Lee, Jin Soo, Sohn, Sung-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291207/
https://www.ncbi.nlm.nih.gov/pubmed/32422921
http://dx.doi.org/10.3390/jcm9051471
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author Yoo, Joonsang
Hong, Jeong-Ho
Lee, Seong-Joon
Kim, Yong-Won
Hong, Ji Man
Kim, Chang-Hyun
Choi, Jin Wook
Kang, Dong-Hun
Kim, Yong-Sun
Hwang, Yang-Ha
Lee, Jin Soo
Sohn, Sung-Il
author_facet Yoo, Joonsang
Hong, Jeong-Ho
Lee, Seong-Joon
Kim, Yong-Won
Hong, Ji Man
Kim, Chang-Hyun
Choi, Jin Wook
Kang, Dong-Hun
Kim, Yong-Sun
Hwang, Yang-Ha
Lee, Jin Soo
Sohn, Sung-Il
author_sort Yoo, Joonsang
collection PubMed
description Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. We compared the characteristics of patients with and without AKI and independent factors associated with AKI after EVT. We also investigated the effects of AKI on functional outcomes and mortality at 3 months. Of the 601 patients analyzed, 59 patients (9.8%) developed AKI and five patients (0.8%) started renal replacement therapy after EVT. In the multivariate analysis, diabetes mellitus (odds ratio (OR), 2.341; 95% CI, 1.283–4.269; p = 0.005), the contrast agent dose (OR, 1.107 per 10 mL; 95% CI, 1.032–1.187; p = 0.004), and unsuccessful reperfusion (OR, 1.909; 95% CI, 1.019–3.520; p = 0.040) were independently associated with AKI. The presence of AKI was associated with a poor functional outcome (OR, 5.145; 95% CI, 2.177–13.850; p < 0.001) and mortality (OR, 8.164; 95% CI, 4.046–16.709; p < 0.001) at 3 months. AKI may also affect the outcomes of ischemic stroke patients undergoing EVT. When implementing EVT, practitioners should be aware of these risk factors.
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spelling pubmed-72912072020-06-17 Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke Yoo, Joonsang Hong, Jeong-Ho Lee, Seong-Joon Kim, Yong-Won Hong, Ji Man Kim, Chang-Hyun Choi, Jin Wook Kang, Dong-Hun Kim, Yong-Sun Hwang, Yang-Ha Lee, Jin Soo Sohn, Sung-Il J Clin Med Article Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. We compared the characteristics of patients with and without AKI and independent factors associated with AKI after EVT. We also investigated the effects of AKI on functional outcomes and mortality at 3 months. Of the 601 patients analyzed, 59 patients (9.8%) developed AKI and five patients (0.8%) started renal replacement therapy after EVT. In the multivariate analysis, diabetes mellitus (odds ratio (OR), 2.341; 95% CI, 1.283–4.269; p = 0.005), the contrast agent dose (OR, 1.107 per 10 mL; 95% CI, 1.032–1.187; p = 0.004), and unsuccessful reperfusion (OR, 1.909; 95% CI, 1.019–3.520; p = 0.040) were independently associated with AKI. The presence of AKI was associated with a poor functional outcome (OR, 5.145; 95% CI, 2.177–13.850; p < 0.001) and mortality (OR, 8.164; 95% CI, 4.046–16.709; p < 0.001) at 3 months. AKI may also affect the outcomes of ischemic stroke patients undergoing EVT. When implementing EVT, practitioners should be aware of these risk factors. MDPI 2020-05-14 /pmc/articles/PMC7291207/ /pubmed/32422921 http://dx.doi.org/10.3390/jcm9051471 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoo, Joonsang
Hong, Jeong-Ho
Lee, Seong-Joon
Kim, Yong-Won
Hong, Ji Man
Kim, Chang-Hyun
Choi, Jin Wook
Kang, Dong-Hun
Kim, Yong-Sun
Hwang, Yang-Ha
Lee, Jin Soo
Sohn, Sung-Il
Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
title Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
title_full Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
title_fullStr Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
title_full_unstemmed Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
title_short Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke
title_sort acute kidney injury after endovascular treatment in patients with acute ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291207/
https://www.ncbi.nlm.nih.gov/pubmed/32422921
http://dx.doi.org/10.3390/jcm9051471
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