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Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis
Endometriosis is a chronic gynecological disease, affecting up to 10% of reproductive-age women. The exact cause of the disease is unknown; however, it is a heritable condition affected by multiple genetic, epigenetic, and environmental factors. Previous studies reported variations in the epigenetic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291215/ https://www.ncbi.nlm.nih.gov/pubmed/32370117 http://dx.doi.org/10.3390/jcm9051309 |
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author | Zubrzycka, Anna Zubrzycki, Marek Perdas, Ewelina Zubrzycka, Maria |
author_facet | Zubrzycka, Anna Zubrzycki, Marek Perdas, Ewelina Zubrzycka, Maria |
author_sort | Zubrzycka, Anna |
collection | PubMed |
description | Endometriosis is a chronic gynecological disease, affecting up to 10% of reproductive-age women. The exact cause of the disease is unknown; however, it is a heritable condition affected by multiple genetic, epigenetic, and environmental factors. Previous studies reported variations in the epigenetic patterns of numerous genes known to be involved in the aberrant modulation of cell cycle steroidogenesis, abnormal hormonal, immune and inflammatory status in endometriosis, apoptosis, adhesion, angiogenesis, proliferation, immune and inflammatory processes, response to hypoxia, steroidogenic pathway and hormone signaling are involved in the pathogenesis of endometriosis. Accumulating evidence suggest that various epigenetic aberrations may contribute to the pathogenesis of endometriosis. Among them, DNA methyltransferases, histone deacetylators, and non-coding microRNAs demonstrate differential expression within endometriotic lesions and in the endometrium of patients with endometriosis. It has been indicated that the identification of epigenetic differences within the DNA or histone proteins may contribute to the discovery of a useful prognostic biomarker, which could aid in the future earlier detection, timely diagnosis, and initiation of a new approach to the treatment of endometriosis, as well as inform us about the effectiveness of treatment and the stage of the disease. As the etiology of endometriosis is highly complex and still far from being fully elucidated, the presented review focuses on different approaches to identify the genetic and epigenetic links of endometriosis and its pathogenesis. |
format | Online Article Text |
id | pubmed-7291215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72912152020-06-17 Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis Zubrzycka, Anna Zubrzycki, Marek Perdas, Ewelina Zubrzycka, Maria J Clin Med Review Endometriosis is a chronic gynecological disease, affecting up to 10% of reproductive-age women. The exact cause of the disease is unknown; however, it is a heritable condition affected by multiple genetic, epigenetic, and environmental factors. Previous studies reported variations in the epigenetic patterns of numerous genes known to be involved in the aberrant modulation of cell cycle steroidogenesis, abnormal hormonal, immune and inflammatory status in endometriosis, apoptosis, adhesion, angiogenesis, proliferation, immune and inflammatory processes, response to hypoxia, steroidogenic pathway and hormone signaling are involved in the pathogenesis of endometriosis. Accumulating evidence suggest that various epigenetic aberrations may contribute to the pathogenesis of endometriosis. Among them, DNA methyltransferases, histone deacetylators, and non-coding microRNAs demonstrate differential expression within endometriotic lesions and in the endometrium of patients with endometriosis. It has been indicated that the identification of epigenetic differences within the DNA or histone proteins may contribute to the discovery of a useful prognostic biomarker, which could aid in the future earlier detection, timely diagnosis, and initiation of a new approach to the treatment of endometriosis, as well as inform us about the effectiveness of treatment and the stage of the disease. As the etiology of endometriosis is highly complex and still far from being fully elucidated, the presented review focuses on different approaches to identify the genetic and epigenetic links of endometriosis and its pathogenesis. MDPI 2020-05-02 /pmc/articles/PMC7291215/ /pubmed/32370117 http://dx.doi.org/10.3390/jcm9051309 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zubrzycka, Anna Zubrzycki, Marek Perdas, Ewelina Zubrzycka, Maria Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis |
title | Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis |
title_full | Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis |
title_fullStr | Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis |
title_full_unstemmed | Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis |
title_short | Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis |
title_sort | genetic, epigenetic, and steroidogenic modulation mechanisms in endometriosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291215/ https://www.ncbi.nlm.nih.gov/pubmed/32370117 http://dx.doi.org/10.3390/jcm9051309 |
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