Modulation of mTORC1 Signaling Pathway by HIV-1

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely...

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Detalles Bibliográficos
Autores principales: Akbay, Burkitkan, Shmakova, Anna, Vassetzky, Yegor, Dokudovskaya, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291251/
https://www.ncbi.nlm.nih.gov/pubmed/32354054
http://dx.doi.org/10.3390/cells9051090
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author Akbay, Burkitkan
Shmakova, Anna
Vassetzky, Yegor
Dokudovskaya, Svetlana
author_facet Akbay, Burkitkan
Shmakova, Anna
Vassetzky, Yegor
Dokudovskaya, Svetlana
author_sort Akbay, Burkitkan
collection PubMed
description Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.
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spelling pubmed-72912512020-06-17 Modulation of mTORC1 Signaling Pathway by HIV-1 Akbay, Burkitkan Shmakova, Anna Vassetzky, Yegor Dokudovskaya, Svetlana Cells Review Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication. MDPI 2020-04-28 /pmc/articles/PMC7291251/ /pubmed/32354054 http://dx.doi.org/10.3390/cells9051090 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Akbay, Burkitkan
Shmakova, Anna
Vassetzky, Yegor
Dokudovskaya, Svetlana
Modulation of mTORC1 Signaling Pathway by HIV-1
title Modulation of mTORC1 Signaling Pathway by HIV-1
title_full Modulation of mTORC1 Signaling Pathway by HIV-1
title_fullStr Modulation of mTORC1 Signaling Pathway by HIV-1
title_full_unstemmed Modulation of mTORC1 Signaling Pathway by HIV-1
title_short Modulation of mTORC1 Signaling Pathway by HIV-1
title_sort modulation of mtorc1 signaling pathway by hiv-1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291251/
https://www.ncbi.nlm.nih.gov/pubmed/32354054
http://dx.doi.org/10.3390/cells9051090
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