Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection

Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has be...

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Autores principales: Kanda, Tatsuo, Sasaki, Reina, Masuzaki, Ryota, Matsumoto, Naoki, Ogawa, Masahiro, Moriyama, Mitsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291253/
https://www.ncbi.nlm.nih.gov/pubmed/32408660
http://dx.doi.org/10.3390/v12050533
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author Kanda, Tatsuo
Sasaki, Reina
Masuzaki, Ryota
Matsumoto, Naoki
Ogawa, Masahiro
Moriyama, Mitsuhiko
author_facet Kanda, Tatsuo
Sasaki, Reina
Masuzaki, Ryota
Matsumoto, Naoki
Ogawa, Masahiro
Moriyama, Mitsuhiko
author_sort Kanda, Tatsuo
collection PubMed
description Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.
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spelling pubmed-72912532020-06-17 Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection Kanda, Tatsuo Sasaki, Reina Masuzaki, Ryota Matsumoto, Naoki Ogawa, Masahiro Moriyama, Mitsuhiko Viruses Review Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs. MDPI 2020-05-12 /pmc/articles/PMC7291253/ /pubmed/32408660 http://dx.doi.org/10.3390/v12050533 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kanda, Tatsuo
Sasaki, Reina
Masuzaki, Ryota
Matsumoto, Naoki
Ogawa, Masahiro
Moriyama, Mitsuhiko
Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
title Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
title_full Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
title_fullStr Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
title_full_unstemmed Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
title_short Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
title_sort cell culture systems and drug targets for hepatitis a virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291253/
https://www.ncbi.nlm.nih.gov/pubmed/32408660
http://dx.doi.org/10.3390/v12050533
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