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Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer

Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gl...

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Autores principales: Hassn Mesrati, Malak, Behrooz, Amir Barzegar, Y. Abuhamad, Asmaa, Syahir, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291262/
https://www.ncbi.nlm.nih.gov/pubmed/32429463
http://dx.doi.org/10.3390/cells9051236
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author Hassn Mesrati, Malak
Behrooz, Amir Barzegar
Y. Abuhamad, Asmaa
Syahir, Amir
author_facet Hassn Mesrati, Malak
Behrooz, Amir Barzegar
Y. Abuhamad, Asmaa
Syahir, Amir
author_sort Hassn Mesrati, Malak
collection PubMed
description Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gliomas and play vital roles in driving tumor growth due to their competency in self-renewal and proliferation. Studies of gliomas have recognized CSCs via specific markers. This review comprehensively examines the current knowledge of the most significant CSCs markers in gliomas in general and in glioblastoma in particular and specifically focuses on their outlook and importance in gliomas CSCs research. We suggest that CSCs should be the superior therapeutic approach by directly targeting the markers. In addition, we highlight the association of these markers with each other in relation to their cascading pathways, and interactions with functional miRNAs, providing the role of the networks axes in glioblastoma signaling pathways.
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spelling pubmed-72912622020-06-17 Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer Hassn Mesrati, Malak Behrooz, Amir Barzegar Y. Abuhamad, Asmaa Syahir, Amir Cells Review Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gliomas and play vital roles in driving tumor growth due to their competency in self-renewal and proliferation. Studies of gliomas have recognized CSCs via specific markers. This review comprehensively examines the current knowledge of the most significant CSCs markers in gliomas in general and in glioblastoma in particular and specifically focuses on their outlook and importance in gliomas CSCs research. We suggest that CSCs should be the superior therapeutic approach by directly targeting the markers. In addition, we highlight the association of these markers with each other in relation to their cascading pathways, and interactions with functional miRNAs, providing the role of the networks axes in glioblastoma signaling pathways. MDPI 2020-05-16 /pmc/articles/PMC7291262/ /pubmed/32429463 http://dx.doi.org/10.3390/cells9051236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hassn Mesrati, Malak
Behrooz, Amir Barzegar
Y. Abuhamad, Asmaa
Syahir, Amir
Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer
title Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer
title_full Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer
title_fullStr Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer
title_full_unstemmed Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer
title_short Understanding Glioblastoma Biomarkers: Knocking a Mountain with a Hammer
title_sort understanding glioblastoma biomarkers: knocking a mountain with a hammer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291262/
https://www.ncbi.nlm.nih.gov/pubmed/32429463
http://dx.doi.org/10.3390/cells9051236
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