Cargando…

Roflumilast in Severely Ill Patients with Chronic Obstructive Pulmonary Disease with Frequent Exacerbations: Risk of Pneumonia Hospitalization and Severe Exacerbations

Roflumilast is given as an add-on to inhalation medication in patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Animal experiments have documented deleterious effects of roflumilast in bacterial infections, but trials have not reported the risk of bacterial infection...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alispahic, Imane Achir, Sørensen, Rikke, Eklöf, Josefin, Sivapalan, Pradeesh, Løkke, Anders, Seersholm, Niels, Vestergaard, Jakob Hedemark, Jensen, Jens-Ulrik Stæhr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291283/ https://www.ncbi.nlm.nih.gov/pubmed/32408645 http://dx.doi.org/10.3390/jcm9051442

Ejemplares similares

Depressive symptoms among patients with COPD according to smoking status: a Danish nationwide case–control study of 21 184 patients
por: Vestergaard, Jakob Hedemark, et al.
Publicado: (2020)

The Association between Use of ICS and Psychiatric Symptoms in Patients with COPD—A Nationwide Cohort Study of 49,500 Patients
por: Jordan, Alexander, et al.
Publicado: (2021)

COPD exacerbations: the impact of long versus short courses of oral corticosteroids on mortality and pneumonia: nationwide data on 67 000 patients with COPD followed for 12 months
por: Sivapalan, Pradeesh, et al.
Publicado: (2019)

Risk of Chronic Obstructive Pulmonary Disease Exacerbation in Patients Who Use Methotrexate—A Nationwide Study of 58,580 Outpatients
por: Bergsøe, Christina Marisa, et al.
Publicado: (2021)

Calcium Channel Blockers and the Risk of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Study of 48,488 Outpatients
por: Rastoder, Ema, et al.
Publicado: (2023)

Sedating antihistamine treatment with promethazine in patients with severe COPD with and without asthma: death and severe exacerbations in a nationwide register study
por: Bonnesen, Barbara, et al.
Publicado: (2023)

Use of inhaled corticosteroids and risk of acquiring Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease
por: Eklöf, Josefin, et al.
Publicado: (2022)

Antibiotic treatment in acute exacerbation of COPD: patient outcomes with amoxicillin vs. amoxicillin/clavulanic acid—data from 43,636 outpatients
por: Bagge, Kristian, et al.
Publicado: (2021)

The Impact of Social Distancing in 2020 on Admission Rates for Exacerbations in Asthma: A Nationwide Cohort Study
por: Toennesen, Louise Lindhardt, et al.
Publicado: (2022)

Renin–angiotensin–system inhibitors and the risk of exacerbations in chronic obstructive pulmonary disease: a nationwide registry study
por: Vilstrup, Frida, et al.
Publicado: (2023)

Major cardiovascular events in patients with severe COPD with and without asthma: a nationwide cohort study
por: Bonnesen, Barbara, et al.
Publicado: (2022)

Mortality and exacerbations associated with Stenotrophomonas maltophilia in chronic obstructive pulmonary disease. A regional cohort study of 22,689 outpatients
por: Rønn, Christian, et al.
Publicado: (2023)

Acute Lung Injury in Critically Ill Patients: Actin-Scavenger Gelsolin Signals Prolonged Respiratory Failure
por: Holm, Freja Stæhr, et al.
Publicado: (2019)

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits
por: Mathioudakis, Alexander G, et al.
Publicado: (2020)

A multi-center randomized, controlled, open-label trial evaluating the effects of eosinophil-guided corticosteroid-sparing therapy in hospitalised patients with COPD exacerbations – The CORTICO steroid reduction in COPD (CORTICO-COP) study protocol
por: Sivapalan, Pradeesh, et al.
Publicado: (2017)

Inhaled corticosteroids and risk of lower respiratory tract infection with Moraxella catarrhalis in patients with chronic obstructive pulmonary disease
por: Johnsen, Rikke Helin, et al.
Publicado: (2023)

Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients
por: Rastoder, Ema, et al.
Publicado: (2021)

Recent developments in the management of severe asthma
por: Meteran, Howraman, et al.
Publicado: (2022)

Biomarkers of Acute Lung Injury The Individualized Approach: for Phenotyping, Risk Stratification and Treatment Surveillance
por: Murray, Daniel D., et al.
Publicado: (2019)

Inhalation devices and inhaled corticosteroids particle size influence on severe pneumonia in patients with chronic obstructive pulmonary disease: a nationwide cohort study
por: Heerfordt, Christian Kjer, et al.
Publicado: (2023)

Hypoxemia and not hyperoxemia predicts worse outcome in severe COPD exacerbations - an observational study
por: Sandau, Charlotte, et al.
Publicado: (2022)

Treatment with prophylactic oral anticoagulants and the risk of mortality in COVID-19 patients: a nationwide cohort study
por: Altaraihi, Sarah, et al.
Publicado: (2023)

Efficacy of Roflumilast in Bronchiectasis Patients with Frequent Exacerbations: A Double-Blinded, Randomized, Placebo-Controlled Pilot Clinical Trial
por: Juthong, Siwasak, et al.
Publicado: (2022)

Effect of different corticosteroid regimes for hospitalised patients with exacerbated COPD: pooled analysis of individual participant data from the REDUCE and CORTICO-COP trials
por: Sivapalan, Pradeesh, et al.
Publicado: (2021)

Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? the REACT study protocol
por: Calverley, Peter MA, et al.
Publicado: (2012)

Neutrophil-to-Lymphocyte Ratio Predicts Clinical Outcome of Severe Acute Exacerbation of COPD in Frequent Exacerbators
por: Lu, Fang-Ying, et al.
Publicado: (2021)

Adrenal suppression in patients with chronic obstructive pulmonary disease treated with glucocorticoids: Role of specific glucocorticoid receptor polymorphisms
por: Sivapalan, Pradeesh, et al.
Publicado: (2022)

Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma
por: Goh, Ken Junyang, et al.
Publicado: (2017)

Characterization Associated with the Frequent Severe Exacerbator Phenotype in COPD Patients
por: Wu, Yao-Kuang, et al.
Publicado: (2021)

Frequent exacerbators in severe asthma: Focus on clinical and transcriptional factors
por: Thomson, Neil C.
Publicado: (2022)

Treatment Response Biomarkers in Asthma and COPD
por: Meteran, Howraman, et al.
Publicado: (2021)

Association between anticoagulant therapy, exacerbations and mortality in a Danish cohort of patients with Chronic Obstructive Pulmonary Disease
por: Kristensen, A, et al.
Publicado: (2022)

SARS-CoV-2 and risk of psychiatric hospital admission and use of psychopharmaceuticals: A nationwide registry study of 4,585,083 adult Danish citizens
por: Rømer, Valdemar, et al.
Publicado: (2023)

The phenotype of concurrent chronic bronchitis and frequent exacerbations in patients with severe COPD attending Swedish secondary care units
por: Sundh, Josefin, et al.
Publicado: (2015)

Comorbidity as a contributor to frequent severe acute exacerbation in COPD patients
por: Jeong, Suk Hyeon, et al.
Publicado: (2016)

The impact on severe exacerbations of establishing a cross-sectorial lung team for patients with COPD at high risk of exacerbating: a pilot study
por: Iversen, Birgit Refsgaard, et al.
Publicado: (2021)

Roflumilast, a Novel Phosphodiesterase 4 Inhibitor, for COPD Patients with a History of Exacerbations
por: Field, Stephen K.
Publicado: (2011)

Incidence of community-acquired pneumonia hospitalisation in persons with bronchiectasis during the COVID-19 lockdown in Denmark: a retrospective cohort study
por: Rømer, Valdemar, et al.
Publicado: (2023)

Risk of Malignancy in Patients with Asthma-COPD Overlap Compared to Patients with COPD without Asthma
por: Bonnesen, Barbara, et al.
Publicado: (2022)

Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients
por: Malinovschi, Andrei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_bigtfed8qud8f1166ke5oqv9mq