HMTase Inhibitors as a Potential Epigenetic-Based Therapeutic Approach for Friedreich’s Ataxia

Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigates reduced transcription. As a consequence, reduced levels of frataxin protein lead to mitochondrial iron accumulation, ox...

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Detalles Bibliográficos
Autores principales: Sherzai, Mursal, Valle, Adamo, Perry, Nicholas, Kalef-Ezra, Ester, Al-Mahdawi, Sahar, Pook, Mark, Anjomani Virmouni, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291394/
https://www.ncbi.nlm.nih.gov/pubmed/32582297
http://dx.doi.org/10.3389/fgene.2020.00584

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