A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure

The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue...

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Detalles Bibliográficos
Autores principales: Wit, Jan M., Bidlingmaier, Martin, de Bruin, Christiaan, Oostdijk, Wilma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291410/
https://www.ncbi.nlm.nih.gov/pubmed/31842524
http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0176
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author Wit, Jan M.
Bidlingmaier, Martin
de Bruin, Christiaan
Oostdijk, Wilma
author_facet Wit, Jan M.
Bidlingmaier, Martin
de Bruin, Christiaan
Oostdijk, Wilma
author_sort Wit, Jan M.
collection PubMed
description The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between zero to -2 SDS.
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spelling pubmed-72914102020-06-23 A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure Wit, Jan M. Bidlingmaier, Martin de Bruin, Christiaan Oostdijk, Wilma J Clin Res Pediatr Endocrinol Review The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between zero to -2 SDS. Galenos Publishing 2020-06 2020-06-03 /pmc/articles/PMC7291410/ /pubmed/31842524 http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0176 Text en ©Copyright 2020 by Turkish Pediatric Endocrinology and Diabetes Society | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wit, Jan M.
Bidlingmaier, Martin
de Bruin, Christiaan
Oostdijk, Wilma
A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
title A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
title_full A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
title_fullStr A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
title_full_unstemmed A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
title_short A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure
title_sort proposal for the interpretation of serum igf-i concentration as part of laboratory screening in children with growth failure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291410/
https://www.ncbi.nlm.nih.gov/pubmed/31842524
http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0176
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