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The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome

BACKGROUND: In early autoimmune neuroinflammation, interferon (IFN)γ and its upregulation of the immunoproteasome (iP) is pathologic. However, during chronic multiple sclerosis (MS), IFNγ has protective properties. Although dysregulation of the iP has been implicated in neurodegeneration, its functi...

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Detalles Bibliográficos
Autores principales:	Smith, Brandon C., Sinyuk, Maksim, Jenkins, Julius E., Psenicka, Morgan W., Williams, Jessica L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291495/ https://www.ncbi.nlm.nih.gov/pubmed/32532298 http://dx.doi.org/10.1186/s12974-020-01861-x

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