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Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells
BACKGROUND: RNF43 and its homolog ZNRF3 are transmembrane E3 ubiquitin ligases frequently mutated in many human cancer types. Their main role relays on the inhibition of canonical Wnt signaling by the negative regulation of frizzled receptors and LRP5/6 co-receptors levels at the plasma membrane. In...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291719/ https://www.ncbi.nlm.nih.gov/pubmed/32527265 http://dx.doi.org/10.1186/s12964-020-00559-0 |