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The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau
INTRODUCTION: Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in West Africa. In the current study we describe the HIV Care continuum and prev...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291728/ https://www.ncbi.nlm.nih.gov/pubmed/32532294 http://dx.doi.org/10.1186/s12981-020-00290-3 |
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author | Lindman, Jacob Djalo, Mamadu Aliu Biai, Ansu Månsson, Fredrik Esbjörnsson, Joakim Jansson, Marianne Medstrand, Patrik Norrgren, Hans |
author_facet | Lindman, Jacob Djalo, Mamadu Aliu Biai, Ansu Månsson, Fredrik Esbjörnsson, Joakim Jansson, Marianne Medstrand, Patrik Norrgren, Hans |
author_sort | Lindman, Jacob |
collection | PubMed |
description | INTRODUCTION: Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in West Africa. In the current study we describe the HIV Care continuum and prevalence of HIVDR among FSW in Guinea-Bissau. METHODS: A venue-based recruitment and peer-referral of FSW was used in seven cities in Guinea-Bissau from October 2014 to September 2017. We administered a questionnaire, performed discriminatory HIV-testing and collected blood specimens for CD4 count, viral load and HIVDR genotyping. RESULTS: The survey included 440 FSW. The overall HIV-prevalence among FSW was 26.8%. Of the HIV-1 (HIV-1 single- or dually HIV-1/HIV-2) infected FSW (N = 104), 58.7% were previously diagnosed with HIV-1 at enrolment and 41.4% reported taking antiretroviral therapy (ART) compared to 28.6% of the HIV-2 single-infected FSW (N = 14). Among HIV-1 infected FSW on ART (N = 43), 55.8% were virally suppressed (< 1000 copies/ml) and of all HIV-1 infected FSW, 29.8% were virally suppressed. Among ART experienced FSW (N = 22), 50.0% had HIVDR. HIVDR was also found in 9.4% of treatment naïve FSW (N = 53). CONCLUSION: The majority of FSW who knew their HIV status received ART, however a large proportion of FSW were not aware of their HIV positive status. This translated into a great majority of the HIV-infected FSW not being virally suppressed. Amongst treatment naïve FSW nearly a tenth had HIVDR, suggesting that sexual transmission of HIVDR is occurring in this at-risk-population. |
format | Online Article Text |
id | pubmed-7291728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72917282020-06-12 The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau Lindman, Jacob Djalo, Mamadu Aliu Biai, Ansu Månsson, Fredrik Esbjörnsson, Joakim Jansson, Marianne Medstrand, Patrik Norrgren, Hans AIDS Res Ther Research INTRODUCTION: Female sex workers (FSW) are considered a key group for HIV transmissions in sub-Saharan Africa. The HIV Care Continuum and HIV drug resistance (HIVDR) among FSW has not been well studied in most countries in West Africa. In the current study we describe the HIV Care continuum and prevalence of HIVDR among FSW in Guinea-Bissau. METHODS: A venue-based recruitment and peer-referral of FSW was used in seven cities in Guinea-Bissau from October 2014 to September 2017. We administered a questionnaire, performed discriminatory HIV-testing and collected blood specimens for CD4 count, viral load and HIVDR genotyping. RESULTS: The survey included 440 FSW. The overall HIV-prevalence among FSW was 26.8%. Of the HIV-1 (HIV-1 single- or dually HIV-1/HIV-2) infected FSW (N = 104), 58.7% were previously diagnosed with HIV-1 at enrolment and 41.4% reported taking antiretroviral therapy (ART) compared to 28.6% of the HIV-2 single-infected FSW (N = 14). Among HIV-1 infected FSW on ART (N = 43), 55.8% were virally suppressed (< 1000 copies/ml) and of all HIV-1 infected FSW, 29.8% were virally suppressed. Among ART experienced FSW (N = 22), 50.0% had HIVDR. HIVDR was also found in 9.4% of treatment naïve FSW (N = 53). CONCLUSION: The majority of FSW who knew their HIV status received ART, however a large proportion of FSW were not aware of their HIV positive status. This translated into a great majority of the HIV-infected FSW not being virally suppressed. Amongst treatment naïve FSW nearly a tenth had HIVDR, suggesting that sexual transmission of HIVDR is occurring in this at-risk-population. BioMed Central 2020-06-12 /pmc/articles/PMC7291728/ /pubmed/32532294 http://dx.doi.org/10.1186/s12981-020-00290-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lindman, Jacob Djalo, Mamadu Aliu Biai, Ansu Månsson, Fredrik Esbjörnsson, Joakim Jansson, Marianne Medstrand, Patrik Norrgren, Hans The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau |
title | The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau |
title_full | The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau |
title_fullStr | The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau |
title_full_unstemmed | The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau |
title_short | The HIV care continuum and HIV-1 drug resistance among female sex workers: a key population in Guinea-Bissau |
title_sort | hiv care continuum and hiv-1 drug resistance among female sex workers: a key population in guinea-bissau |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291728/ https://www.ncbi.nlm.nih.gov/pubmed/32532294 http://dx.doi.org/10.1186/s12981-020-00290-3 |
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