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Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation
Neuroimaging evidence suggests that the development of the hippocampus, a brain structure critical for memory function, contributes to the improvements of episodic memory between middle childhood to adulthood. However, investigations on age differences in hippocampal activation and functional connec...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291774/ https://www.ncbi.nlm.nih.gov/pubmed/32581749 http://dx.doi.org/10.3389/fnhum.2020.00204 |
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author | Tang, Lingfei Pruitt, Patrick J. Yu, Qijing Homayouni, Roya Daugherty, Ana M. Damoiseaux, Jessica S. Ofen, Noa |
author_facet | Tang, Lingfei Pruitt, Patrick J. Yu, Qijing Homayouni, Roya Daugherty, Ana M. Damoiseaux, Jessica S. Ofen, Noa |
author_sort | Tang, Lingfei |
collection | PubMed |
description | Neuroimaging evidence suggests that the development of the hippocampus, a brain structure critical for memory function, contributes to the improvements of episodic memory between middle childhood to adulthood. However, investigations on age differences in hippocampal activation and functional connectivity and their contributions to the development of memory have yielded mixed results. Given the known structural and functional heterogeneity along the long axis of the hippocampus, we investigated age differences in the activation and functional connectivity in hippocampal subregions with a cross-sectional sample of 96 participants ages 8–25 years. We found that anterior and posterior hippocampus supported memory formation, and there was overall stability in memory-related hippocampal activation with age. Without taking account of memory outcome, direct contrast between subregions showed higher functional connectivity of anterior, compared to the posterior hippocampus, with regions in the inferior frontal and lateral temporal lobes, and higher functional connectivity of posterior, compared to the anterior hippocampus, with regions in the medial and superior frontal, inferior parietal, and occipital lobes. A direct contrast between the memory-related connectivity patterns of anterior and posterior hippocampus identified a region in the medial frontal cortex, with which anterior and posterior hippocampus was differentially functionally connected. Finally, we identified age differences in memory-related differential hippocampal functional connectivity with several frontal and visual/sensory cortices, underscoring the importance of examining age differences in the patterns of hippocampal connectivity. Moreover, the specific patterns of differential anterior and posterior functional connectivity indicate an increase in the functional specialization along the long axis of the hippocampus and a dynamic shift in hippocampal connectivity patterns that supports memory development. |
format | Online Article Text |
id | pubmed-7291774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72917742020-06-23 Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation Tang, Lingfei Pruitt, Patrick J. Yu, Qijing Homayouni, Roya Daugherty, Ana M. Damoiseaux, Jessica S. Ofen, Noa Front Hum Neurosci Human Neuroscience Neuroimaging evidence suggests that the development of the hippocampus, a brain structure critical for memory function, contributes to the improvements of episodic memory between middle childhood to adulthood. However, investigations on age differences in hippocampal activation and functional connectivity and their contributions to the development of memory have yielded mixed results. Given the known structural and functional heterogeneity along the long axis of the hippocampus, we investigated age differences in the activation and functional connectivity in hippocampal subregions with a cross-sectional sample of 96 participants ages 8–25 years. We found that anterior and posterior hippocampus supported memory formation, and there was overall stability in memory-related hippocampal activation with age. Without taking account of memory outcome, direct contrast between subregions showed higher functional connectivity of anterior, compared to the posterior hippocampus, with regions in the inferior frontal and lateral temporal lobes, and higher functional connectivity of posterior, compared to the anterior hippocampus, with regions in the medial and superior frontal, inferior parietal, and occipital lobes. A direct contrast between the memory-related connectivity patterns of anterior and posterior hippocampus identified a region in the medial frontal cortex, with which anterior and posterior hippocampus was differentially functionally connected. Finally, we identified age differences in memory-related differential hippocampal functional connectivity with several frontal and visual/sensory cortices, underscoring the importance of examining age differences in the patterns of hippocampal connectivity. Moreover, the specific patterns of differential anterior and posterior functional connectivity indicate an increase in the functional specialization along the long axis of the hippocampus and a dynamic shift in hippocampal connectivity patterns that supports memory development. Frontiers Media S.A. 2020-06-05 /pmc/articles/PMC7291774/ /pubmed/32581749 http://dx.doi.org/10.3389/fnhum.2020.00204 Text en Copyright © 2020 Tang, Pruitt, Yu, Homayouni, Daugherty, Damoiseaux and Ofen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Tang, Lingfei Pruitt, Patrick J. Yu, Qijing Homayouni, Roya Daugherty, Ana M. Damoiseaux, Jessica S. Ofen, Noa Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation |
title | Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation |
title_full | Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation |
title_fullStr | Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation |
title_full_unstemmed | Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation |
title_short | Differential Functional Connectivity in Anterior and Posterior Hippocampus Supporting the Development of Memory Formation |
title_sort | differential functional connectivity in anterior and posterior hippocampus supporting the development of memory formation |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291774/ https://www.ncbi.nlm.nih.gov/pubmed/32581749 http://dx.doi.org/10.3389/fnhum.2020.00204 |
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