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Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition

Aurora kinases are a family of serine/threonine kinases vital for cell division. Because of the overexpression of Aurora kinases in a broad range of cancers and their important roles in mitosis, inhibitors targeting Aurora kinases have attracted attention in cancer therapy. VX-680 is an effective pa...

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Detalles Bibliográficos
Autores principales:	Huang, Min, Feng, Xu, Su, Dan, Wang, Gang, Wang, Chao, Tang, Mengfan, Paulucci-Holthauzen, Adriana, Hart, Traver, Chen, Junjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291820/ https://www.ncbi.nlm.nih.gov/pubmed/32300176 http://dx.doi.org/10.1038/s41388-020-1296-2

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