Nanopore sequencing as a scalable, cost-effective platform for analyzing polyclonal vector integration sites following clinical T cell therapy

BACKGROUND: Analysis of vector integration sites in gene-modified cells can provide critical information on clonality and potential biological impact on nearby genes. Current short-read next-generation sequencing methods require specialized instruments and large batch runs. METHODS: We used nanopore...

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Detalles Bibliográficos
Autores principales: Zhang, Ping, Ganesamoorthy, Devika, Nguyen, Son Hoang, Au, Raymond, Coin, Lachlan J, Tey, Siok-Keen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292043/
https://www.ncbi.nlm.nih.gov/pubmed/32527930
http://dx.doi.org/10.1136/jitc-2019-000299

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