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Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma

INTRODUCTION: A radiation recall reaction in previously irradiated lungs is known as radiation recall pneumonitis. We encountered a rare case of radiation recall pneumonitis induced by nivolumab 9 months after palliative radiotherapy to the ribs. CASE PRESENTATION: The patient was a 69‐year‐old woma...

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Autores principales: Nakamura, Kenji, Okubo, Kazutoshi, Takahashi, Takeshi, Mitsumori, Kenji, Ishigaki, Takashi, Ohnishi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292071/
https://www.ncbi.nlm.nih.gov/pubmed/32743367
http://dx.doi.org/10.1002/iju5.12032
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author Nakamura, Kenji
Okubo, Kazutoshi
Takahashi, Takeshi
Mitsumori, Kenji
Ishigaki, Takashi
Ohnishi, Hiroyuki
author_facet Nakamura, Kenji
Okubo, Kazutoshi
Takahashi, Takeshi
Mitsumori, Kenji
Ishigaki, Takashi
Ohnishi, Hiroyuki
author_sort Nakamura, Kenji
collection PubMed
description INTRODUCTION: A radiation recall reaction in previously irradiated lungs is known as radiation recall pneumonitis. We encountered a rare case of radiation recall pneumonitis induced by nivolumab 9 months after palliative radiotherapy to the ribs. CASE PRESENTATION: The patient was a 69‐year‐old woman with renal cell carcinoma. She had received various drugs and palliative irradiation, which was followed by nivolumab treatment, for renal cell carcinoma. Three days after the initial nivolumab administration, she presented with respiratory symptoms. On the basis of chest computed tomography findings, she was diagnosed with nivolumab‐induced radiation recall pneumonitis and treated with prednisolone (1 mg/kg). The condition resolved rapidly, and chest computed tomography 4 months after nivolumab cessation revealed interval resolution of the lung consolidation and persistent tumor shrinkage. CONCLUSION: Physicians should consider the risk of radiation recall pneumonitis during treatment with immune checkpoint inhibitors in patients who have received previous thoracic radiotherapy.
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spelling pubmed-72920712020-07-30 Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma Nakamura, Kenji Okubo, Kazutoshi Takahashi, Takeshi Mitsumori, Kenji Ishigaki, Takashi Ohnishi, Hiroyuki IJU Case Rep Case Reports INTRODUCTION: A radiation recall reaction in previously irradiated lungs is known as radiation recall pneumonitis. We encountered a rare case of radiation recall pneumonitis induced by nivolumab 9 months after palliative radiotherapy to the ribs. CASE PRESENTATION: The patient was a 69‐year‐old woman with renal cell carcinoma. She had received various drugs and palliative irradiation, which was followed by nivolumab treatment, for renal cell carcinoma. Three days after the initial nivolumab administration, she presented with respiratory symptoms. On the basis of chest computed tomography findings, she was diagnosed with nivolumab‐induced radiation recall pneumonitis and treated with prednisolone (1 mg/kg). The condition resolved rapidly, and chest computed tomography 4 months after nivolumab cessation revealed interval resolution of the lung consolidation and persistent tumor shrinkage. CONCLUSION: Physicians should consider the risk of radiation recall pneumonitis during treatment with immune checkpoint inhibitors in patients who have received previous thoracic radiotherapy. John Wiley and Sons Inc. 2018-11-26 /pmc/articles/PMC7292071/ /pubmed/32743367 http://dx.doi.org/10.1002/iju5.12032 Text en © 2018 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Nakamura, Kenji
Okubo, Kazutoshi
Takahashi, Takeshi
Mitsumori, Kenji
Ishigaki, Takashi
Ohnishi, Hiroyuki
Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
title Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
title_full Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
title_fullStr Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
title_full_unstemmed Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
title_short Radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
title_sort radiation recall pneumonitis induced by nivolumab in a patient with renal cell carcinoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292071/
https://www.ncbi.nlm.nih.gov/pubmed/32743367
http://dx.doi.org/10.1002/iju5.12032
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