Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma

INTRODUCTION: Although the tumors are often easily detected, a considerable number of patients with female urethral carcinoma are diagnosed in an advance stage. Thus, no evidence‐based therapeutic approach has been established. We herein report our experience in the treatment of three female patient...

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Autores principales: Ninomiya, Sahoko, Kawahara, Takashi, Mochizuki, Taku, Ishiguro, Yukari, Miyoshi, Yasuhide, Otani, Masako, Yao, Masahiro, Miyamoto, Hiroshi, Uemura, Hiroji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292119/
https://www.ncbi.nlm.nih.gov/pubmed/32743365
http://dx.doi.org/10.1002/iju5.12029
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author Ninomiya, Sahoko
Kawahara, Takashi
Mochizuki, Taku
Ishiguro, Yukari
Miyoshi, Yasuhide
Otani, Masako
Yao, Masahiro
Miyamoto, Hiroshi
Uemura, Hiroji
author_facet Ninomiya, Sahoko
Kawahara, Takashi
Mochizuki, Taku
Ishiguro, Yukari
Miyoshi, Yasuhide
Otani, Masako
Yao, Masahiro
Miyamoto, Hiroshi
Uemura, Hiroji
author_sort Ninomiya, Sahoko
collection PubMed
description INTRODUCTION: Although the tumors are often easily detected, a considerable number of patients with female urethral carcinoma are diagnosed in an advance stage. Thus, no evidence‐based therapeutic approach has been established. We herein report our experience in the treatment of three female patients with urethral carcinoma. We also examined the expression of PD‐L1 and CTLA‐4. CASE PRESENTATION: Three female patients pathologically diagnosed with urethral carcinoma, including urothelial carcinoma, squamous cell carcinoma, and adenocarcinoma, between 2013 and 2017 were analyzed in this study. Two patients underwent urethrectomy with cystostomy. Immunohistochemistry was performed to assess the levels of PD‐L1 and CTLA‐4 expression in patients with urethral carcinoma. Eleven control cases of urethral carcinoma tissue were also stained. CONCLUSION: This study revealed the expression of PD‐L1 and CTLA‐4 in female urethral carcinomas.
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spelling pubmed-72921192020-07-30 Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma Ninomiya, Sahoko Kawahara, Takashi Mochizuki, Taku Ishiguro, Yukari Miyoshi, Yasuhide Otani, Masako Yao, Masahiro Miyamoto, Hiroshi Uemura, Hiroji IJU Case Rep Case Reports INTRODUCTION: Although the tumors are often easily detected, a considerable number of patients with female urethral carcinoma are diagnosed in an advance stage. Thus, no evidence‐based therapeutic approach has been established. We herein report our experience in the treatment of three female patients with urethral carcinoma. We also examined the expression of PD‐L1 and CTLA‐4. CASE PRESENTATION: Three female patients pathologically diagnosed with urethral carcinoma, including urothelial carcinoma, squamous cell carcinoma, and adenocarcinoma, between 2013 and 2017 were analyzed in this study. Two patients underwent urethrectomy with cystostomy. Immunohistochemistry was performed to assess the levels of PD‐L1 and CTLA‐4 expression in patients with urethral carcinoma. Eleven control cases of urethral carcinoma tissue were also stained. CONCLUSION: This study revealed the expression of PD‐L1 and CTLA‐4 in female urethral carcinomas. John Wiley and Sons Inc. 2018-11-23 /pmc/articles/PMC7292119/ /pubmed/32743365 http://dx.doi.org/10.1002/iju5.12029 Text en © 2018 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Ninomiya, Sahoko
Kawahara, Takashi
Mochizuki, Taku
Ishiguro, Yukari
Miyoshi, Yasuhide
Otani, Masako
Yao, Masahiro
Miyamoto, Hiroshi
Uemura, Hiroji
Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma
title Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma
title_full Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma
title_fullStr Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma
title_full_unstemmed Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma
title_short Expression of PD‐L1 and CTLA‐4 in female urethral carcinoma
title_sort expression of pd‐l1 and ctla‐4 in female urethral carcinoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292119/
https://www.ncbi.nlm.nih.gov/pubmed/32743365
http://dx.doi.org/10.1002/iju5.12029
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