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Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein
INTRODUCTION: In urothelial cancer, several paraneoplastic syndromes can be triggered by the aberrant expression of hormones, growth factors or lymphokines by tumor cells. CASE PRESENTATION: A 71‐year‐old female patient underwent radical cystectomy for muscle‐invasive urothelial cancer. Shortly afte...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292181/ https://www.ncbi.nlm.nih.gov/pubmed/32743371 http://dx.doi.org/10.1002/iju5.12036 |
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author | Hoshi, Senji Numahata, Kenji Morozumi, Kento Katumata, Yuuki Kuromoto, Akito Takai, Yuuki Hoshi, Kiyotugu Bilim, Vladimir Sasagawa, Isoji |
author_facet | Hoshi, Senji Numahata, Kenji Morozumi, Kento Katumata, Yuuki Kuromoto, Akito Takai, Yuuki Hoshi, Kiyotugu Bilim, Vladimir Sasagawa, Isoji |
author_sort | Hoshi, Senji |
collection | PubMed |
description | INTRODUCTION: In urothelial cancer, several paraneoplastic syndromes can be triggered by the aberrant expression of hormones, growth factors or lymphokines by tumor cells. CASE PRESENTATION: A 71‐year‐old female patient underwent radical cystectomy for muscle‐invasive urothelial cancer. Shortly after the operation, the patient presented with a leukemoid reaction and hypercalcemia. Computed tomography scans revealed a rapidly progressing tumor on the left pelvic side, and serum levels of granulocyte‐colony stimulating factor, parathyroid hormone‐related protein, and beta human chorionic gonadotropin were elevated. The patient also tested positive for serum squamous cell carcinoma antigen. Hypercalcemia was successfully treated with denosumab. However, the patient's leukocyte counts steadily increased, her condition deteriorated and she passed away. CONCLUSION: To the best of our knowledge, this is the first report of urothelial cancer that tested positive for four tumor markers. The findings support the idea that poorly differentiated bladder carcinomas can ectopically secrete multiple proteins causing pleiotropic paraneoplastic syndromes. |
format | Online Article Text |
id | pubmed-7292181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72921812020-07-30 Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein Hoshi, Senji Numahata, Kenji Morozumi, Kento Katumata, Yuuki Kuromoto, Akito Takai, Yuuki Hoshi, Kiyotugu Bilim, Vladimir Sasagawa, Isoji IJU Case Rep Case Reports INTRODUCTION: In urothelial cancer, several paraneoplastic syndromes can be triggered by the aberrant expression of hormones, growth factors or lymphokines by tumor cells. CASE PRESENTATION: A 71‐year‐old female patient underwent radical cystectomy for muscle‐invasive urothelial cancer. Shortly after the operation, the patient presented with a leukemoid reaction and hypercalcemia. Computed tomography scans revealed a rapidly progressing tumor on the left pelvic side, and serum levels of granulocyte‐colony stimulating factor, parathyroid hormone‐related protein, and beta human chorionic gonadotropin were elevated. The patient also tested positive for serum squamous cell carcinoma antigen. Hypercalcemia was successfully treated with denosumab. However, the patient's leukocyte counts steadily increased, her condition deteriorated and she passed away. CONCLUSION: To the best of our knowledge, this is the first report of urothelial cancer that tested positive for four tumor markers. The findings support the idea that poorly differentiated bladder carcinomas can ectopically secrete multiple proteins causing pleiotropic paraneoplastic syndromes. John Wiley and Sons Inc. 2018-12-14 /pmc/articles/PMC7292181/ /pubmed/32743371 http://dx.doi.org/10.1002/iju5.12036 Text en © 2018 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Hoshi, Senji Numahata, Kenji Morozumi, Kento Katumata, Yuuki Kuromoto, Akito Takai, Yuuki Hoshi, Kiyotugu Bilim, Vladimir Sasagawa, Isoji Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
title | Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
title_full | Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
title_fullStr | Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
title_full_unstemmed | Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
title_short | Bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
title_sort | bladder cancer metastasis producing beta‐human chorionic gonadotropin, squamous cell carcinoma antigen, granulocyte‐colony stimulating factor, and parathyroid hormone‐related protein |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292181/ https://www.ncbi.nlm.nih.gov/pubmed/32743371 http://dx.doi.org/10.1002/iju5.12036 |
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