Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling

Tumor progression in the host leads to severe impairment of intrathymic T-cell differentiation/maturation, leading to the paralysis of cellular anti-tumor immunity. Such suppression manifests the erosion of CD4(+)CD8(+) double-positive (DP) immature thymocytes and a gradual increase in CD4(−)CD8(−)...

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Detalles Bibliográficos
Autores principales: Guha, Ipsita, Bhuniya, Avishek, Shukla, Divanshu, Patidar, Ashok, Nandi, Partha, Saha, Akata, Dasgupta, Shayani, Ganguly, Nilanjan, Ghosh, Sweta, Nair, Arathi, Majumdar, Subrata, Saha, Bhaskar, Storkus, Walter J., Baral, Rathindranath, Bose, Anamika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292239/
https://www.ncbi.nlm.nih.gov/pubmed/32582141
http://dx.doi.org/10.3389/fimmu.2020.00898

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