Brain dynamics for confidence-weighted learning

Learning in a changing, uncertain environment is a difficult problem. A popular solution is to predict future observations and then use surprising outcomes to update those predictions. However, humans also have a sense of confidence that characterizes the precision of their predictions. Bayesian models use a confidence-weighting principle to regulate learning: for a given surprise, the update is smaller when the confidence about the prediction was higher. Prior behavioral evidence indicates that human learning adheres to this confidence-weighting principle. Here, we explored the human brain dynamics sub-tending the confidence-weighting of learning using magneto-encephalography (MEG). During our volatile probability learning task, subjects’ confidence reports conformed with Bayesian inference. MEG revealed several stimulus-evoked brain responses whose amplitude reflected surprise, and some of them were further shaped by confidence: surprise amplified the stimulus-evoked response whereas confidence dampened it. Confidence about predictions also modulated several aspects of the brain state: pupil-linked arousal and beta-range (15–30 Hz) oscillations. The brain state in turn modulated specific stimulus-evoked surprise responses following the confidence-weighting principle. Our results thus indicate that there exist, in the human brain, signals reflecting surprise that are dampened by confidence in a way that is appropriate for learning according to Bayesian inference. They also suggest a mechanism for confidence-weighted learning: confidence about predictions would modulate intrinsic properties of the brain state to amplify or dampen surprise responses evoked by discrepant observations.