A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer

We describe a patient with a testosterone-producing metastasis discovered during the follow-up of prostate cancer. The patient had a history of a Leydig cell tumor (LCT) in the right testicle for which he underwent radical orchiectomy at the age of 60 years. Within a year after orchiectomy, he was d...

Descripción completa

Detalles Bibliográficos
Autores principales: Stokkel, Laura, van der Poel, Henk G., Langbein, Sigrun I., Kerst, J. Martijn, de Jong, Jeroen, van Rhijn, Bas W. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292439/
https://www.ncbi.nlm.nih.gov/pubmed/32565659
http://dx.doi.org/10.4103/UA.UA_38_19
_version_ 1783546115280338944
author Stokkel, Laura
van der Poel, Henk G.
Langbein, Sigrun I.
Kerst, J. Martijn
de Jong, Jeroen
van Rhijn, Bas W. G.
author_facet Stokkel, Laura
van der Poel, Henk G.
Langbein, Sigrun I.
Kerst, J. Martijn
de Jong, Jeroen
van Rhijn, Bas W. G.
author_sort Stokkel, Laura
collection PubMed
description We describe a patient with a testosterone-producing metastasis discovered during the follow-up of prostate cancer. The patient had a history of a Leydig cell tumor (LCT) in the right testicle for which he underwent radical orchiectomy at the age of 60 years. Within a year after orchiectomy, he was diagnosed with prostate cancer. He received a radical prostatectomy with pelvic lymph node dissection. Due to recurrent prostate cancer, he underwent salvage radiation to the prostatic fossa and pelvic lymph node stations with hormonal treatment for 3 years. After approximately 1.5 years of chemical castration, a significant increase in testosterone level occurred. Further, diagnostic evaluations and surgery revealed a testosterone-producing LCT metastasis in the retroperitoneum.
format Online
Article
Text
id pubmed-7292439
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-72924392020-06-19 A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer Stokkel, Laura van der Poel, Henk G. Langbein, Sigrun I. Kerst, J. Martijn de Jong, Jeroen van Rhijn, Bas W. G. Urol Ann Case Report We describe a patient with a testosterone-producing metastasis discovered during the follow-up of prostate cancer. The patient had a history of a Leydig cell tumor (LCT) in the right testicle for which he underwent radical orchiectomy at the age of 60 years. Within a year after orchiectomy, he was diagnosed with prostate cancer. He received a radical prostatectomy with pelvic lymph node dissection. Due to recurrent prostate cancer, he underwent salvage radiation to the prostatic fossa and pelvic lymph node stations with hormonal treatment for 3 years. After approximately 1.5 years of chemical castration, a significant increase in testosterone level occurred. Further, diagnostic evaluations and surgery revealed a testosterone-producing LCT metastasis in the retroperitoneum. Wolters Kluwer - Medknow 2020 2020-04-14 /pmc/articles/PMC7292439/ /pubmed/32565659 http://dx.doi.org/10.4103/UA.UA_38_19 Text en Copyright: © 2020 Urology Annals http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Stokkel, Laura
van der Poel, Henk G.
Langbein, Sigrun I.
Kerst, J. Martijn
de Jong, Jeroen
van Rhijn, Bas W. G.
A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
title A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
title_full A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
title_fullStr A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
title_full_unstemmed A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
title_short A testosterone-producing Leydig cell tumor metastasis during hormonal treatment of prostate cancer
title_sort testosterone-producing leydig cell tumor metastasis during hormonal treatment of prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292439/
https://www.ncbi.nlm.nih.gov/pubmed/32565659
http://dx.doi.org/10.4103/UA.UA_38_19
work_keys_str_mv AT stokkellaura atestosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT vanderpoelhenkg atestosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT langbeinsigruni atestosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT kerstjmartijn atestosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT dejongjeroen atestosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT vanrhijnbaswg atestosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT stokkellaura testosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT vanderpoelhenkg testosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT langbeinsigruni testosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT kerstjmartijn testosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT dejongjeroen testosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer
AT vanrhijnbaswg testosteroneproducingleydigcelltumormetastasisduringhormonaltreatmentofprostatecancer

Ejemplares similares