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HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection
The highest recorded hepatitis C virus (HCV) prevalence worldwide is in Egypt. A high prevalence of hepatitis E virus (HEV) in chronic liver disease has been reported. The aim of this study was to study prevalence, incidence, and outcome of HCV infection in an Egyptian Nile Delta village and the rel...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292573/ https://www.ncbi.nlm.nih.gov/pubmed/32533486 http://dx.doi.org/10.1007/s11356-020-09591-6 |
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author | Elhendawy, Mohammed Abo-Ali, Lobna Abd-Elsalam, Sherief Hagras, Maha M. Kabbash, Ibrahim Mansour, Loai Atia, Sherief Esmat, Gamal Abo-ElAzm, Abdel-Raouf El-Kalla, Ferial Kobtan, Abdelrahman |
author_facet | Elhendawy, Mohammed Abo-Ali, Lobna Abd-Elsalam, Sherief Hagras, Maha M. Kabbash, Ibrahim Mansour, Loai Atia, Sherief Esmat, Gamal Abo-ElAzm, Abdel-Raouf El-Kalla, Ferial Kobtan, Abdelrahman |
author_sort | Elhendawy, Mohammed |
collection | PubMed |
description | The highest recorded hepatitis C virus (HCV) prevalence worldwide is in Egypt. A high prevalence of hepatitis E virus (HEV) in chronic liver disease has been reported. The aim of this study was to study prevalence, incidence, and outcome of HCV infection in an Egyptian Nile Delta village and the relation between HEV infection and HCV-related chronic hepatic affection. This prospective cohort study included 2085 Nagreej village residents. Mass HCV screening was conducted and testing for HEV antibodies among HCV-infected patients performed. The annual incidence of HCV was recorded. Five hundred five (24.22%) of the tested villagers were positive for HCV RNA. Prevalence escalated with age and male sex. The main recorded risk factors were a history of surgery, dental procedures, hospitalization, blood transfusion, and antischistosomal treatment. HEV IgG antibody was positive in 71.4% of individuals with chronic HCV and 96.1% with advanced liver disease (cirrhosis ± hepatocellular carcinoma (HCC)). After 1 year, 29 of the 1390 HCV Ab negative villagers had a positive HCV PCR, placing an annual incidence of new HCV infections at 2.09%. The Egyptian HCV prevalence remains high with infection particularly among the elderly. The annual incidence in a small Nile Delta village is 2.086%. HCV-HEV co-infection may lead to a worse prognosis among Egyptians with chronic liver disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11356-020-09591-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7292573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-72925732020-06-14 HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection Elhendawy, Mohammed Abo-Ali, Lobna Abd-Elsalam, Sherief Hagras, Maha M. Kabbash, Ibrahim Mansour, Loai Atia, Sherief Esmat, Gamal Abo-ElAzm, Abdel-Raouf El-Kalla, Ferial Kobtan, Abdelrahman Environ Sci Pollut Res Int Research Article The highest recorded hepatitis C virus (HCV) prevalence worldwide is in Egypt. A high prevalence of hepatitis E virus (HEV) in chronic liver disease has been reported. The aim of this study was to study prevalence, incidence, and outcome of HCV infection in an Egyptian Nile Delta village and the relation between HEV infection and HCV-related chronic hepatic affection. This prospective cohort study included 2085 Nagreej village residents. Mass HCV screening was conducted and testing for HEV antibodies among HCV-infected patients performed. The annual incidence of HCV was recorded. Five hundred five (24.22%) of the tested villagers were positive for HCV RNA. Prevalence escalated with age and male sex. The main recorded risk factors were a history of surgery, dental procedures, hospitalization, blood transfusion, and antischistosomal treatment. HEV IgG antibody was positive in 71.4% of individuals with chronic HCV and 96.1% with advanced liver disease (cirrhosis ± hepatocellular carcinoma (HCC)). After 1 year, 29 of the 1390 HCV Ab negative villagers had a positive HCV PCR, placing an annual incidence of new HCV infections at 2.09%. The Egyptian HCV prevalence remains high with infection particularly among the elderly. The annual incidence in a small Nile Delta village is 2.086%. HCV-HEV co-infection may lead to a worse prognosis among Egyptians with chronic liver disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11356-020-09591-6) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-06-12 2020 /pmc/articles/PMC7292573/ /pubmed/32533486 http://dx.doi.org/10.1007/s11356-020-09591-6 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Research Article Elhendawy, Mohammed Abo-Ali, Lobna Abd-Elsalam, Sherief Hagras, Maha M. Kabbash, Ibrahim Mansour, Loai Atia, Sherief Esmat, Gamal Abo-ElAzm, Abdel-Raouf El-Kalla, Ferial Kobtan, Abdelrahman HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection |
title | HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection |
title_full | HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection |
title_fullStr | HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection |
title_full_unstemmed | HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection |
title_short | HCV and HEV: two players in an Egyptian village, a study of prevalence, incidence, and co-infection |
title_sort | hcv and hev: two players in an egyptian village, a study of prevalence, incidence, and co-infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292573/ https://www.ncbi.nlm.nih.gov/pubmed/32533486 http://dx.doi.org/10.1007/s11356-020-09591-6 |
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