Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response

We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the com...

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Detalles Bibliográficos
Autores principales: Wilmes, Dunja, Schui, Daniela, Held, Jürgen, Ackermann, Sina, Geipel, Udo, Emrich, Kai, Winkelmann, Ernst-Joachim, Rickerts, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292894/
https://www.ncbi.nlm.nih.gov/pubmed/32551217
http://dx.doi.org/10.1016/j.mmcr.2020.05.007
Descripción
Sumario:We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the complement fixation test after two years. The (1 → 3)-ß-D-glucan levels normalised after two years without increase after cessation of antifungal therapy. Biomarkers in serum may guide treatment decisions in disseminated coccidioidomycosis.

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