Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response

We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the com...

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Autores principales: Wilmes, Dunja, Schui, Daniela, Held, Jürgen, Ackermann, Sina, Geipel, Udo, Emrich, Kai, Winkelmann, Ernst-Joachim, Rickerts, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292894/
https://www.ncbi.nlm.nih.gov/pubmed/32551217
http://dx.doi.org/10.1016/j.mmcr.2020.05.007
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author Wilmes, Dunja
Schui, Daniela
Held, Jürgen
Ackermann, Sina
Geipel, Udo
Emrich, Kai
Winkelmann, Ernst-Joachim
Rickerts, Volker
author_facet Wilmes, Dunja
Schui, Daniela
Held, Jürgen
Ackermann, Sina
Geipel, Udo
Emrich, Kai
Winkelmann, Ernst-Joachim
Rickerts, Volker
author_sort Wilmes, Dunja
collection PubMed
description We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the complement fixation test after two years. The (1 → 3)-ß-D-glucan levels normalised after two years without increase after cessation of antifungal therapy. Biomarkers in serum may guide treatment decisions in disseminated coccidioidomycosis.
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spelling pubmed-72928942020-06-17 Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response Wilmes, Dunja Schui, Daniela Held, Jürgen Ackermann, Sina Geipel, Udo Emrich, Kai Winkelmann, Ernst-Joachim Rickerts, Volker Med Mycol Case Rep Case Report We describe a patient with a disseminated coccidioidomycosis. Biomarkers in serum during itraconazole therapy showed a rapid clearing of Coccidioides DNA as detected by PCR. Coccidioides antibody detection by lateral flow assay became negative after one year and decreased from 1:64 to 1:8 in the complement fixation test after two years. The (1 → 3)-ß-D-glucan levels normalised after two years without increase after cessation of antifungal therapy. Biomarkers in serum may guide treatment decisions in disseminated coccidioidomycosis. Elsevier 2020-05-30 /pmc/articles/PMC7292894/ /pubmed/32551217 http://dx.doi.org/10.1016/j.mmcr.2020.05.007 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wilmes, Dunja
Schui, Daniela
Held, Jürgen
Ackermann, Sina
Geipel, Udo
Emrich, Kai
Winkelmann, Ernst-Joachim
Rickerts, Volker
Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
title Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
title_full Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
title_fullStr Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
title_full_unstemmed Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
title_short Disseminated coccidioidomycosis: Monitoring of serologic markers for treatment response
title_sort disseminated coccidioidomycosis: monitoring of serologic markers for treatment response
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292894/
https://www.ncbi.nlm.nih.gov/pubmed/32551217
http://dx.doi.org/10.1016/j.mmcr.2020.05.007
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