Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient's request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dup...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwamuro, Masaya, Murakami, Toshi, Tanaka, Takehiro, Oka, Shohei, Kawano, Seiji, Kawahara, Yoshiro, Okada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292988/
https://www.ncbi.nlm.nih.gov/pubmed/32566328
http://dx.doi.org/10.1155/2020/6381670
_version_ 1783546208018497536
author Iwamuro, Masaya
Murakami, Toshi
Tanaka, Takehiro
Oka, Shohei
Kawano, Seiji
Kawahara, Yoshiro
Okada, Hiroyuki
author_facet Iwamuro, Masaya
Murakami, Toshi
Tanaka, Takehiro
Oka, Shohei
Kawano, Seiji
Kawahara, Yoshiro
Okada, Hiroyuki
author_sort Iwamuro, Masaya
collection PubMed
description A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient's request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.
format Online
Article
Text
id pubmed-7292988
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-72929882020-06-18 Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab Iwamuro, Masaya Murakami, Toshi Tanaka, Takehiro Oka, Shohei Kawano, Seiji Kawahara, Yoshiro Okada, Hiroyuki Case Rep Gastrointest Med Case Report A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient's request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab. Hindawi 2020-06-03 /pmc/articles/PMC7292988/ /pubmed/32566328 http://dx.doi.org/10.1155/2020/6381670 Text en Copyright © 2020 Masaya Iwamuro et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Iwamuro, Masaya
Murakami, Toshi
Tanaka, Takehiro
Oka, Shohei
Kawano, Seiji
Kawahara, Yoshiro
Okada, Hiroyuki
Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_full Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_fullStr Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_full_unstemmed Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_short Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab
title_sort eosinophilic gastritis in a patient previously treated with dupilumab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292988/
https://www.ncbi.nlm.nih.gov/pubmed/32566328
http://dx.doi.org/10.1155/2020/6381670
work_keys_str_mv AT iwamuromasaya eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab
AT murakamitoshi eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab
AT tanakatakehiro eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab
AT okashohei eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab
AT kawanoseiji eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab
AT kawaharayoshiro eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab
AT okadahiroyuki eosinophilicgastritisinapatientpreviouslytreatedwithdupilumab

Ejemplares similares