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RNF8 has both KU-dependent and independent roles in chromosomal break repair

Chromosomal double strand breaks (DSBs) can initiate several signaling events, such as ubiquitination, however the precise influence of such signaling on DSB repair outcomes remains poorly understood. With an RNA interference screen, we found that the E3 ubiquitin ligase RNF8 suppresses a deletion r...

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Detalles Bibliográficos
Autores principales:	Tsai, Linda Jillianne, Lopezcolorado, Felicia Wednesday, Bhargava, Ragini, Mendez-Dorantes, Carlos, Jahanshir, Eva, Stark, Jeremy M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293022/ https://www.ncbi.nlm.nih.gov/pubmed/32427332 http://dx.doi.org/10.1093/nar/gkaa380

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