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GSK-3 is an RNA polymerase II phospho-CTD kinase

We have previously found that UV-induced DNA damage causes hyperphosphorylation of the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), inhibition of transcriptional elongation and changes in alternative splicing (AS) due to kinetic coupling between transcription and splicing. In an unbi...

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Detalles Bibliográficos
Autores principales: Nieto Moreno, Nicolás, Villafañez, Florencia, Giono, Luciana E, Cuenca, Carmen, Soria, Gastón, Muñoz, Manuel J, Kornblihtt, Alberto R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293024/
https://www.ncbi.nlm.nih.gov/pubmed/32374842
http://dx.doi.org/10.1093/nar/gkaa322