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GSK-3 is an RNA polymerase II phospho-CTD kinase
We have previously found that UV-induced DNA damage causes hyperphosphorylation of the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), inhibition of transcriptional elongation and changes in alternative splicing (AS) due to kinetic coupling between transcription and splicing. In an unbi...
Autores principales: | Nieto Moreno, Nicolás, Villafañez, Florencia, Giono, Luciana E, Cuenca, Carmen, Soria, Gastón, Muñoz, Manuel J, Kornblihtt, Alberto R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293024/ https://www.ncbi.nlm.nih.gov/pubmed/32374842 http://dx.doi.org/10.1093/nar/gkaa322 |
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