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Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence

Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) second messengers in response to viral infection of bacteria and archaea, potentiating an immune response by binding and activating ancillary effector nucleases such as Csx1. As these effectors are not specific for invading nucleic acids...

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Detalles Bibliográficos
Autores principales:	Samolygo, Aleksei, Athukoralage, Januka S, Graham, Shirley, White, Malcolm F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293037/ https://www.ncbi.nlm.nih.gov/pubmed/32347937 http://dx.doi.org/10.1093/nar/gkaa298

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