Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling

The DNA damage checkpoint halts cell cycle progression in G2 in response to genotoxic insults. Central to the execution of cell cycle arrest is the checkpoint-induced stabilization of securin-separase complex (yeast Pds1-Esp1). The checkpoint kinases Chk1 and Chk2 (yeast Chk1 and Rad53) are thought...

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Detalles Bibliográficos
Autores principales: Yam, Candice Qiu Xia, Chia, David Boy, Shi, Idina, Lim, Hong Hwa, Surana, Uttam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293041/
https://www.ncbi.nlm.nih.gov/pubmed/32402080
http://dx.doi.org/10.1093/nar/gkaa355

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