Rationally designed peptide-based inhibitor of Aβ(42) fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease

Amyloid beta peptide (Aβ(42)) aggregation in the brain is thought to be responsible for the onset of Alzheimer's disease, an insidious condition without an effective treatment or cure. Hence, a strategy to prevent aggregation and subsequent toxicity is crucial. Bio-inspired peptide-based molecu...

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Detalles Bibliográficos
Autores principales: Horsley, John R., Jovcevski, Blagojce, Wegener, Kate L., Yu, Jingxian, Pukala, Tara L., Abell, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293109/
https://www.ncbi.nlm.nih.gov/pubmed/32427336
http://dx.doi.org/10.1042/BCJ20200290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293109/
https://www.ncbi.nlm.nih.gov/pubmed/32427336
http://dx.doi.org/10.1042/BCJ20200290

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