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Thermogenic adipocytes: lineage, function and therapeutic potential
Metabolic inflexibility, defined as the inability to respond or adapt to metabolic demand, is now recognised as a driving factor behind many pathologies associated with obesity and the metabolic syndrome. Adipose tissue plays a pivotal role in the ability of an organism to sense, adapt to and counte...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293110/ https://www.ncbi.nlm.nih.gov/pubmed/32539124 http://dx.doi.org/10.1042/BCJ20200298 |
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author | Pollard, Alice E. Carling, David |
author_facet | Pollard, Alice E. Carling, David |
author_sort | Pollard, Alice E. |
collection | PubMed |
description | Metabolic inflexibility, defined as the inability to respond or adapt to metabolic demand, is now recognised as a driving factor behind many pathologies associated with obesity and the metabolic syndrome. Adipose tissue plays a pivotal role in the ability of an organism to sense, adapt to and counteract environmental changes. It provides a buffer in times of nutrient excess, a fuel reserve during starvation and the ability to resist cold-stress through non-shivering thermogenesis. Recent advances in single-cell RNA sequencing combined with lineage tracing, transcriptomic and proteomic analyses have identified novel adipocyte progenitors that give rise to specialised adipocytes with diverse functions, some of which have the potential to be exploited therapeutically. This review will highlight the common and distinct functions of well-known adipocyte populations with respect to their lineage and plasticity, as well as introducing the most recent members of the adipocyte family and their roles in whole organism energy homeostasis. Finally, this article will outline some of the more preliminary findings from large data sets generated by single-cell transcriptomics of mouse and human adipose tissue and their implications for the field, both for discovery and for therapy. |
format | Online Article Text |
id | pubmed-7293110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72931102020-06-18 Thermogenic adipocytes: lineage, function and therapeutic potential Pollard, Alice E. Carling, David Biochem J Diabetes & Metabolic Disorders Metabolic inflexibility, defined as the inability to respond or adapt to metabolic demand, is now recognised as a driving factor behind many pathologies associated with obesity and the metabolic syndrome. Adipose tissue plays a pivotal role in the ability of an organism to sense, adapt to and counteract environmental changes. It provides a buffer in times of nutrient excess, a fuel reserve during starvation and the ability to resist cold-stress through non-shivering thermogenesis. Recent advances in single-cell RNA sequencing combined with lineage tracing, transcriptomic and proteomic analyses have identified novel adipocyte progenitors that give rise to specialised adipocytes with diverse functions, some of which have the potential to be exploited therapeutically. This review will highlight the common and distinct functions of well-known adipocyte populations with respect to their lineage and plasticity, as well as introducing the most recent members of the adipocyte family and their roles in whole organism energy homeostasis. Finally, this article will outline some of the more preliminary findings from large data sets generated by single-cell transcriptomics of mouse and human adipose tissue and their implications for the field, both for discovery and for therapy. Portland Press Ltd. 2020-06-12 2020-06-12 /pmc/articles/PMC7293110/ /pubmed/32539124 http://dx.doi.org/10.1042/BCJ20200298 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of Imperial College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. |
spellingShingle | Diabetes & Metabolic Disorders Pollard, Alice E. Carling, David Thermogenic adipocytes: lineage, function and therapeutic potential |
title | Thermogenic adipocytes: lineage, function and therapeutic potential |
title_full | Thermogenic adipocytes: lineage, function and therapeutic potential |
title_fullStr | Thermogenic adipocytes: lineage, function and therapeutic potential |
title_full_unstemmed | Thermogenic adipocytes: lineage, function and therapeutic potential |
title_short | Thermogenic adipocytes: lineage, function and therapeutic potential |
title_sort | thermogenic adipocytes: lineage, function and therapeutic potential |
topic | Diabetes & Metabolic Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293110/ https://www.ncbi.nlm.nih.gov/pubmed/32539124 http://dx.doi.org/10.1042/BCJ20200298 |
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