Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels

Melanoma represents the most serious type of skin cancer. Although recent years have seen advances using targeted and immunotherapies, most patients remain at high risk for tumor recurrence. Here we show that IRAK-M, a negative regulator of MyD88 signaling, is deficient or low in melanoma and expres...

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Detalles Bibliográficos
Autores principales: Geng, Degui, Ciavattone, Nicholas, Lasola, Jackline Joy, Shrestha, Rojesh, Sanchez, Amelia, Guo, Jitao, Vlk, Alexandra, Younis, Rania, Wang, Lucy, Brown, Alex J., Zhang, Yuji, Velasco-Gonzalez, Cruz, Tan, Aik-Choon, Davila, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293221/
https://www.ncbi.nlm.nih.gov/pubmed/32533049
http://dx.doi.org/10.1038/s42003-020-1033-y

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