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Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness

Gulf War Illness (GWI) is a chronic health condition that appeared in Veterans after returning home from the Gulf War. The primary symptoms linked to deployment are posttraumatic stress disorder, mood disorders, GI problems and chronic fatigue. At first glance, these symptoms are difficult to ascrib...

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Autores principales: Angoa-Pérez, Mariana, Zagorac, Branislava, Francescutti, Dina M., Winters, Andrew D., Greenberg, Jonathan M., Ahmad, Madison M., Manning, Shannon D., Gulbransen, Brian D., Theis, Kevin R., Kuhn, Donald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293234/
https://www.ncbi.nlm.nih.gov/pubmed/32533086
http://dx.doi.org/10.1038/s41598-020-66833-w
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author Angoa-Pérez, Mariana
Zagorac, Branislava
Francescutti, Dina M.
Winters, Andrew D.
Greenberg, Jonathan M.
Ahmad, Madison M.
Manning, Shannon D.
Gulbransen, Brian D.
Theis, Kevin R.
Kuhn, Donald M.
author_facet Angoa-Pérez, Mariana
Zagorac, Branislava
Francescutti, Dina M.
Winters, Andrew D.
Greenberg, Jonathan M.
Ahmad, Madison M.
Manning, Shannon D.
Gulbransen, Brian D.
Theis, Kevin R.
Kuhn, Donald M.
author_sort Angoa-Pérez, Mariana
collection PubMed
description Gulf War Illness (GWI) is a chronic health condition that appeared in Veterans after returning home from the Gulf War. The primary symptoms linked to deployment are posttraumatic stress disorder, mood disorders, GI problems and chronic fatigue. At first glance, these symptoms are difficult to ascribe to a single pathological mechanism. However, it is now clear that each symptom can be linked individually to alterations in the gut microbiome. The primary objective of the present study was to determine if gut microbiome dysbiosis was evident in a mouse model of GWl. Because the majority of Gulf War Veterans are overweight, a second objective was to determine if a high fat diet (HF) would alter GWI outcomes. We found that the taxonomic structure of the gut microbiome was significantly altered in the GWI model and after HF exposure. Their combined effects were significantly different from either treatment alone. Most treatment-induced changes occurred at the level of phylum in Firmicutes and Bacteroidetes. If mice fed HF were returned to a normal diet, the gut microbiome recovered toward normal levels in both controls and GWI agent-treated mice. These results add support to the hypotheses that dysbiosis in the gut microbiome plays a role in GWI and that life-style risk factors such as an unhealthy diet can accentuate the effects of GWI by impacting the gut microbiome. The reversibility of the effect of HF on the gut microbiome suggests new avenues for treating GWI through dietary intervention.
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spelling pubmed-72932342020-06-15 Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness Angoa-Pérez, Mariana Zagorac, Branislava Francescutti, Dina M. Winters, Andrew D. Greenberg, Jonathan M. Ahmad, Madison M. Manning, Shannon D. Gulbransen, Brian D. Theis, Kevin R. Kuhn, Donald M. Sci Rep Article Gulf War Illness (GWI) is a chronic health condition that appeared in Veterans after returning home from the Gulf War. The primary symptoms linked to deployment are posttraumatic stress disorder, mood disorders, GI problems and chronic fatigue. At first glance, these symptoms are difficult to ascribe to a single pathological mechanism. However, it is now clear that each symptom can be linked individually to alterations in the gut microbiome. The primary objective of the present study was to determine if gut microbiome dysbiosis was evident in a mouse model of GWl. Because the majority of Gulf War Veterans are overweight, a second objective was to determine if a high fat diet (HF) would alter GWI outcomes. We found that the taxonomic structure of the gut microbiome was significantly altered in the GWI model and after HF exposure. Their combined effects were significantly different from either treatment alone. Most treatment-induced changes occurred at the level of phylum in Firmicutes and Bacteroidetes. If mice fed HF were returned to a normal diet, the gut microbiome recovered toward normal levels in both controls and GWI agent-treated mice. These results add support to the hypotheses that dysbiosis in the gut microbiome plays a role in GWI and that life-style risk factors such as an unhealthy diet can accentuate the effects of GWI by impacting the gut microbiome. The reversibility of the effect of HF on the gut microbiome suggests new avenues for treating GWI through dietary intervention. Nature Publishing Group UK 2020-06-12 /pmc/articles/PMC7293234/ /pubmed/32533086 http://dx.doi.org/10.1038/s41598-020-66833-w Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Angoa-Pérez, Mariana
Zagorac, Branislava
Francescutti, Dina M.
Winters, Andrew D.
Greenberg, Jonathan M.
Ahmad, Madison M.
Manning, Shannon D.
Gulbransen, Brian D.
Theis, Kevin R.
Kuhn, Donald M.
Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness
title Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness
title_full Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness
title_fullStr Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness
title_full_unstemmed Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness
title_short Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness
title_sort effects of a high fat diet on gut microbiome dysbiosis in a mouse model of gulf war illness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293234/
https://www.ncbi.nlm.nih.gov/pubmed/32533086
http://dx.doi.org/10.1038/s41598-020-66833-w
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