Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in tumors due to their low abundance. Here, we descr...

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Detalles Bibliográficos
Autores principales: Jalili, Pégah, Bowen, Danae, Langenbucher, Adam, Park, Shinho, Aguirre, Kevin, Corcoran, Ryan B., Fleischman, Angela G., Lawrence, Michael S., Zou, Lee, Buisson, Rémi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293259/
https://www.ncbi.nlm.nih.gov/pubmed/32532990
http://dx.doi.org/10.1038/s41467-020-16802-8

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