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CRISPR artificial splicing factors

Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation. Here we report the engineering of CRISPR Artificial Splicing Factors (CASFx) based on R...

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Detalles Bibliográficos
Autores principales:	Du, Menghan, Jillette, Nathaniel, Zhu, Jacqueline Jufen, Li, Sheng, Cheng, Albert Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293279/ https://www.ncbi.nlm.nih.gov/pubmed/32532987 http://dx.doi.org/10.1038/s41467-020-16806-4

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