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Using human in vitro transcriptome analysis to build trustworthy machine learning models for prediction of animal drug toxicity
During the development of new drugs or compounds there is a requirement for preclinical trials, commonly involving animal tests, to ascertain the safety of the compound prior to human trials. Machine learning techniques could provide an in-silico alternative to animal models for assessing drug toxic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293302/ https://www.ncbi.nlm.nih.gov/pubmed/32533004 http://dx.doi.org/10.1038/s41598-020-66481-0 |