Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum

Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together...

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Detalles Bibliográficos
Autores principales: Xu, Xiaolin, Chen, Xingyue, Yang, Runmei, Li, Zesheng, Zhou, Houguang, Bai, Yanbing, Yu, Meng, Li, Biao, Ding, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293321/
https://www.ncbi.nlm.nih.gov/pubmed/32533030
http://dx.doi.org/10.1038/s41598-020-66552-2
Descripción
Sumario:Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together with comparison of analogues. Compound (1) possess a (5/6/6/5) tetra-hetero-cyclic ring, whereas compound (2) contains a tricyclic system with an unusual bridged ring, which are the first report in Nature. The biological evaluation revealed that dendrocrepine (4) displayed a potent hypoglycemic effect in vitro.

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