Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum

Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together...

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Autores principales: Xu, Xiaolin, Chen, Xingyue, Yang, Runmei, Li, Zesheng, Zhou, Houguang, Bai, Yanbing, Yu, Meng, Li, Biao, Ding, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293321/
https://www.ncbi.nlm.nih.gov/pubmed/32533030
http://dx.doi.org/10.1038/s41598-020-66552-2
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author Xu, Xiaolin
Chen, Xingyue
Yang, Runmei
Li, Zesheng
Zhou, Houguang
Bai, Yanbing
Yu, Meng
Li, Biao
Ding, Gang
author_facet Xu, Xiaolin
Chen, Xingyue
Yang, Runmei
Li, Zesheng
Zhou, Houguang
Bai, Yanbing
Yu, Meng
Li, Biao
Ding, Gang
author_sort Xu, Xiaolin
collection PubMed
description Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together with comparison of analogues. Compound (1) possess a (5/6/6/5) tetra-hetero-cyclic ring, whereas compound (2) contains a tricyclic system with an unusual bridged ring, which are the first report in Nature. The biological evaluation revealed that dendrocrepine (4) displayed a potent hypoglycemic effect in vitro.
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spelling pubmed-72933212020-06-15 Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum Xu, Xiaolin Chen, Xingyue Yang, Runmei Li, Zesheng Zhou, Houguang Bai, Yanbing Yu, Meng Li, Biao Ding, Gang Sci Rep Article Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together with comparison of analogues. Compound (1) possess a (5/6/6/5) tetra-hetero-cyclic ring, whereas compound (2) contains a tricyclic system with an unusual bridged ring, which are the first report in Nature. The biological evaluation revealed that dendrocrepine (4) displayed a potent hypoglycemic effect in vitro. Nature Publishing Group UK 2020-06-12 /pmc/articles/PMC7293321/ /pubmed/32533030 http://dx.doi.org/10.1038/s41598-020-66552-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Xu, Xiaolin
Chen, Xingyue
Yang, Runmei
Li, Zesheng
Zhou, Houguang
Bai, Yanbing
Yu, Meng
Li, Biao
Ding, Gang
Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum
title Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum
title_full Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum
title_fullStr Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum
title_full_unstemmed Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum
title_short Crepidtumines A and B, Two Novel Indolizidine Alkaloids from Dendrobium crepidatum
title_sort crepidtumines a and b, two novel indolizidine alkaloids from dendrobium crepidatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293321/
https://www.ncbi.nlm.nih.gov/pubmed/32533030
http://dx.doi.org/10.1038/s41598-020-66552-2
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