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Different Development Forms of Local Allergic Rhinitis towards Birch

BACKGROUND: Efficacy of allergen immunotherapy (AIT) in local allergic rhinitis (LAR) is a new subject of research. The presence of asthmatic symptoms in patients with LAR in the context of AIT is unexplored. OBJECTIVE: The efficacy and safety of AIT in patients with LAR towards birch pollen were in...

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Autores principales: Bozek, Andrzej, Winterstein, Janne, Galuszka, Beata, Jarzab, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293726/
https://www.ncbi.nlm.nih.gov/pubmed/32596297
http://dx.doi.org/10.1155/2020/3408561
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author Bozek, Andrzej
Winterstein, Janne
Galuszka, Beata
Jarzab, Jerzy
author_facet Bozek, Andrzej
Winterstein, Janne
Galuszka, Beata
Jarzab, Jerzy
author_sort Bozek, Andrzej
collection PubMed
description BACKGROUND: Efficacy of allergen immunotherapy (AIT) in local allergic rhinitis (LAR) is a new subject of research. The presence of asthmatic symptoms in patients with LAR in the context of AIT is unexplored. OBJECTIVE: The efficacy and safety of AIT in patients with LAR towards birch pollen were investigated. The possibility of concomitant local allergic asthma in studied patients and the impact of AIT on it were examined. METHODS: 36 patients with LAR towards birch were included in three years of AIT in a double-blind, placebo-control study. Primary outcome measurement was the mean changes in the combined symptom and medication scores (CSMSs) after AIT, and the second is the changes in the quality of life (QoL). Skin prick tests, serum, nasal allergen-specific IgE to birch, nasal and bronchial provocation challenge tests with birch allergen, methacholine tests, and spirometry were carried out at baseline and after AIT. RESULTS: Mean CSMSs of three years of AIT were significantly decreased in the active group from 5.88 (range: 4.11-9.01) to 1.98 (range: 1.22-4.51; p < 0.05). After three years of AIT, there was a significant increase of toleration for birch allergen from the mean concentration of 6250 ± 1200 SQ-U/ml up to 45000 ± 2500 SQ-U/ml (p = 0.02) during repeated nasal challenges. 16 patients with LAR had the positive results of methacholine tests, and 11 of them had a positive bronchial challenge to birch allergen. After AIT, the significant decrease of bronchial responsiveness to birch allergen in 5 from 7 patients was confirmed (p = 0.03). QoL assessed by the use of the RQLQ score was improved after AIT from 1.84 (95% CI: 1.53-1.97) to 1.45 (95% CI: 1.32-1.62) score in the active group after three years of AIT therapy (p = 0.03). CONCLUSION: AIT to birch can be useful and safe in a patient with local allergic rhinitis and also with concomitant asthmatic symptoms. Further studies are needed.
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spelling pubmed-72937262020-06-25 Different Development Forms of Local Allergic Rhinitis towards Birch Bozek, Andrzej Winterstein, Janne Galuszka, Beata Jarzab, Jerzy Biomed Res Int Research Article BACKGROUND: Efficacy of allergen immunotherapy (AIT) in local allergic rhinitis (LAR) is a new subject of research. The presence of asthmatic symptoms in patients with LAR in the context of AIT is unexplored. OBJECTIVE: The efficacy and safety of AIT in patients with LAR towards birch pollen were investigated. The possibility of concomitant local allergic asthma in studied patients and the impact of AIT on it were examined. METHODS: 36 patients with LAR towards birch were included in three years of AIT in a double-blind, placebo-control study. Primary outcome measurement was the mean changes in the combined symptom and medication scores (CSMSs) after AIT, and the second is the changes in the quality of life (QoL). Skin prick tests, serum, nasal allergen-specific IgE to birch, nasal and bronchial provocation challenge tests with birch allergen, methacholine tests, and spirometry were carried out at baseline and after AIT. RESULTS: Mean CSMSs of three years of AIT were significantly decreased in the active group from 5.88 (range: 4.11-9.01) to 1.98 (range: 1.22-4.51; p < 0.05). After three years of AIT, there was a significant increase of toleration for birch allergen from the mean concentration of 6250 ± 1200 SQ-U/ml up to 45000 ± 2500 SQ-U/ml (p = 0.02) during repeated nasal challenges. 16 patients with LAR had the positive results of methacholine tests, and 11 of them had a positive bronchial challenge to birch allergen. After AIT, the significant decrease of bronchial responsiveness to birch allergen in 5 from 7 patients was confirmed (p = 0.03). QoL assessed by the use of the RQLQ score was improved after AIT from 1.84 (95% CI: 1.53-1.97) to 1.45 (95% CI: 1.32-1.62) score in the active group after three years of AIT therapy (p = 0.03). CONCLUSION: AIT to birch can be useful and safe in a patient with local allergic rhinitis and also with concomitant asthmatic symptoms. Further studies are needed. Hindawi 2020-06-04 /pmc/articles/PMC7293726/ /pubmed/32596297 http://dx.doi.org/10.1155/2020/3408561 Text en Copyright © 2020 Andrzej Bozek et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bozek, Andrzej
Winterstein, Janne
Galuszka, Beata
Jarzab, Jerzy
Different Development Forms of Local Allergic Rhinitis towards Birch
title Different Development Forms of Local Allergic Rhinitis towards Birch
title_full Different Development Forms of Local Allergic Rhinitis towards Birch
title_fullStr Different Development Forms of Local Allergic Rhinitis towards Birch
title_full_unstemmed Different Development Forms of Local Allergic Rhinitis towards Birch
title_short Different Development Forms of Local Allergic Rhinitis towards Birch
title_sort different development forms of local allergic rhinitis towards birch
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293726/
https://www.ncbi.nlm.nih.gov/pubmed/32596297
http://dx.doi.org/10.1155/2020/3408561
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