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Role of Neutrophils in Psoriasis
Psoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293746/ https://www.ncbi.nlm.nih.gov/pubmed/32587871 http://dx.doi.org/10.1155/2020/3709749 |
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author | Wang, Wen-Ming Jin, Hong-Zhong |
author_facet | Wang, Wen-Ming Jin, Hong-Zhong |
author_sort | Wang, Wen-Ming |
collection | PubMed |
description | Psoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may play a role in autoimmune diseases. The neutrophil-to-lymphocyte ratio (NLR), the activity of neutrophils, and the number of NETotic cells were significantly higher in psoriasis patients compared to healthy controls. The number of low-density granulocytes (LDGs) in the blood of psoriasis patients was significantly higher than those in the control blood. Furthermore, neutrophils may play important roles in the cardiovascular risk in psoriasis. However, the exact role of neutrophils in psoriasis remains unclear. In this review, we highlight the role of neutrophils in the pathogenesis of psoriasis. |
format | Online Article Text |
id | pubmed-7293746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72937462020-06-24 Role of Neutrophils in Psoriasis Wang, Wen-Ming Jin, Hong-Zhong J Immunol Res Review Article Psoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may play a role in autoimmune diseases. The neutrophil-to-lymphocyte ratio (NLR), the activity of neutrophils, and the number of NETotic cells were significantly higher in psoriasis patients compared to healthy controls. The number of low-density granulocytes (LDGs) in the blood of psoriasis patients was significantly higher than those in the control blood. Furthermore, neutrophils may play important roles in the cardiovascular risk in psoriasis. However, the exact role of neutrophils in psoriasis remains unclear. In this review, we highlight the role of neutrophils in the pathogenesis of psoriasis. Hindawi 2020-06-05 /pmc/articles/PMC7293746/ /pubmed/32587871 http://dx.doi.org/10.1155/2020/3709749 Text en Copyright © 2020 Wen-Ming Wang and Hong-Zhong Jin. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Wen-Ming Jin, Hong-Zhong Role of Neutrophils in Psoriasis |
title | Role of Neutrophils in Psoriasis |
title_full | Role of Neutrophils in Psoriasis |
title_fullStr | Role of Neutrophils in Psoriasis |
title_full_unstemmed | Role of Neutrophils in Psoriasis |
title_short | Role of Neutrophils in Psoriasis |
title_sort | role of neutrophils in psoriasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293746/ https://www.ncbi.nlm.nih.gov/pubmed/32587871 http://dx.doi.org/10.1155/2020/3709749 |
work_keys_str_mv | AT wangwenming roleofneutrophilsinpsoriasis AT jinhongzhong roleofneutrophilsinpsoriasis |