Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity

A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19...

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Autores principales: Guallar, María Pilar, Meiriño, Rosa, Donat-Vargas, Carolina, Corral, Octavio, Jouvé, Nicolás, Soriano, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293836/
https://www.ncbi.nlm.nih.gov/pubmed/32553720
http://dx.doi.org/10.1016/j.ijid.2020.06.035
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author Guallar, María Pilar
Meiriño, Rosa
Donat-Vargas, Carolina
Corral, Octavio
Jouvé, Nicolás
Soriano, Vicente
author_facet Guallar, María Pilar
Meiriño, Rosa
Donat-Vargas, Carolina
Corral, Octavio
Jouvé, Nicolás
Soriano, Vicente
author_sort Guallar, María Pilar
collection PubMed
description A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.
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spelling pubmed-72938362020-06-15 Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity Guallar, María Pilar Meiriño, Rosa Donat-Vargas, Carolina Corral, Octavio Jouvé, Nicolás Soriano, Vicente Int J Infect Dis Article A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-08 2020-06-14 /pmc/articles/PMC7293836/ /pubmed/32553720 http://dx.doi.org/10.1016/j.ijid.2020.06.035 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Guallar, María Pilar
Meiriño, Rosa
Donat-Vargas, Carolina
Corral, Octavio
Jouvé, Nicolás
Soriano, Vicente
Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
title Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
title_full Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
title_fullStr Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
title_full_unstemmed Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
title_short Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
title_sort inoculum at the time of sars-cov-2 exposure and risk of disease severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293836/
https://www.ncbi.nlm.nih.gov/pubmed/32553720
http://dx.doi.org/10.1016/j.ijid.2020.06.035
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